DegronMD

Uniprot ID: Q96F85

Source protein: CB1 cannabinoid receptor-interacting protein 1

Source gene: CNRIP1

Class: DEG_SCF_FBW7_1

Location: 94:99

E3 ligase: FBXW7

DEGRON score: 0.6963

ASA_SCORE: 73.85

COIL: 0.7932

CONS_SCORE: 0.646

DSS_SCORE: 0.5638

HELIX: 0.02

FCONS_SCORE: 1.0789

RIG_SCORE: 0.7256

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G100A	TCGA-34-A5IX	LUSC	TCGA	VTPTKS	DEG_SCF_FBW7_1	0.3056
p.G100A	DO219136	LUSC	ICGC	VTPTKS	DEG_SCF_FBW7_1	0.3056
p.T86M	TCGA-A5-A0VP	UCEC	TCGA	VTPTKS	DEG_SCF_FBW7_1	0.1111
p.T86M	DO233145	GACA	ICGC	VTPTKS	DEG_SCF_FBW7_1	0.1111
p.T86M	DO42600	UCEC	ICGC	VTPTKS	DEG_SCF_FBW7_1	0.1111
p.T86M	SIDM00710	Small Cell Lung Carcinoma	GDSC	VTPTKS	DEG_SCF_FBW7_1	0.1111
p.T86M	ACH-000394	Lung Cancer	CCLE	VTPTKS	DEG_SCF_FBW7_1	0.1111
p.T86M	NCI-H2081	lung	COSMIC	VTPTKS	DEG_SCF_FBW7_1	0.1111
p.R102W	TCGA-AA-3984	COAD	TCGA	VTPTKS	DEG_SCF_FBW7_1	0.25
p.R102W	TCGA-B5-A3FA	UCEC	TCGA	VTPTKS	DEG_SCF_FBW7_1	0.25
p.R102W	DO9002	COAD	ICGC	VTPTKS	DEG_SCF_FBW7_1	0.25
p.R102W	DO52402	UCEC	ICGC	VTPTKS	DEG_SCF_FBW7_1	0.25
p.D90G	TCGA-AZ-4315	COAD	TCGA	VTPTKS	DEG_SCF_FBW7_1	0.2222
p.D90G	DO8842	COAD	ICGC	VTPTKS	DEG_SCF_FBW7_1	0.2222
p.Q103H	TCGA-ED-A7PZ	LIHC	TCGA	VTPTKS	DEG_SCF_FBW7_1	0.2222
p.Q103H	DO48532	LIHC	ICGC	VTPTKS	DEG_SCF_FBW7_1	0.2222
p.E92K	TCGA-EL-A3GU	THCA	TCGA	VTPTKS	DEG_SCF_FBW7_1	0.2778
p.E92K	DO40411	THCA	ICGC	VTPTKS	DEG_SCF_FBW7_1	0.2778
p.D90E	DO228976	LICA	ICGC	VTPTKS	DEG_SCF_FBW7_1	0.2222
p.P96Q	DO228986	LICA	ICGC	VTPTKS	DEG_SCF_FBW7_1	0.7035
p.T97M	DO45031	LINC	ICGC	VTPTKS	DEG_SCF_FBW7_1	0.6312
p.T97M	ACH-000459	Kidney Cancer	CCLE	VTPTKS	DEG_SCF_FBW7_1	0.6312
p.T86A	SIDM02035	Colorectal Carcinoma	GDSC	VTPTKS	DEG_SCF_FBW7_1	0.1111
p.E92Q	SIDM00032	Bladder Carcinoma	GDSC	VTPTKS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96F85	CB1 cannabinoid receptor-interacting protein 1	DEG_SCF_FBW7_1	94:99	VTPTKS	FBXW7	0.6963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons