DegronMD

Uniprot ID: Q6PKG0

Source protein: La-related protein 1

Source gene: LARP1

Class: DEG_SCF_FBW7_1

Location: 525:530

E3 ligase: FBXW7

DEGRON score: 0.9995

ASA_SCORE: 80.6833

COIL: 0.949

CONS_SCORE: 0.3033

DSS_SCORE: 0.6385

HELIX: 0.0163

FCONS_SCORE: 1.077

RIG_SCORE: 0.6709

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E526D	TCGA-EY-A1GI	UCEC	TCGA	VTPVPT	DEG_SCF_FBW7_1	0.6758
p.E526D	DO41211	UCEC	ICGC	VTPVPT	DEG_SCF_FBW7_1	0.6758
p.E526Q	TCGA-JW-A852	CESC	TCGA	VTPVPT	DEG_SCF_FBW7_1	0.6744
p.E526Q	DO49978	CESC	ICGC	VTPVPT	DEG_SCF_FBW7_1	0.6744
p.M539T	TCGA-LN-A4A6	ESCA	TCGA	VTPVPT	DEG_SCF_FBW7_1	0.5278
p.E537K	DO48270	ESCA	ICGC	VTPVPT	DEG_SCF_FBW7_1	0.1389
p.D521Y	DO229038	LICA	ICGC	VTPVPT	DEG_SCF_FBW7_1	0.6667
p.D529Y	SIDM00971	Breast Carcinoma	GDSC	VTPVPT	DEG_SCF_FBW7_1	0.7325
p.D533Y	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	VTPVPT	DEG_SCF_FBW7_1	0.25
p.D533Y	ACH-000912	Lung Cancer	CCLE	VTPVPT	DEG_SCF_FBW7_1	0.25
p.Q515E	ACH-001063	Ovarian Cancer	CCLE	VTPVPT	DEG_SCF_FBW7_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PKG0	La-related protein 1	DEG_SCF_FBW7_1	525:530	VTPVPT	FBXW7	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons