DegronMD

Uniprot ID: P0C264

Source protein: Uncharacterized serine/threonine-protein kinase SBK3

Source gene: SBK3

Class: DEG_SCF_FBW7_1

Location: 33:38

E3 ligase: FBXW7

DEGRON score: 0.7829

ASA_SCORE: 89.4333

COIL: 0.6563

CONS_SCORE: 0.4907

DSS_SCORE: 0.3402

HELIX: 0.029

FCONS_SCORE: 0.8073

RIG_SCORE: 0.8069

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P35R	DO228483	BRCA	ICGC	VTPVRS	DEG_SCF_FBW7_1	0.7512
p.P35R	DO222990	BTCA	ICGC	VTPVRS	DEG_SCF_FBW7_1	0.7512
p.P35R	DO228941	LICA	ICGC	VTPVRS	DEG_SCF_FBW7_1	0.7512
p.P35R	DO228947	LICA	ICGC	VTPVRS	DEG_SCF_FBW7_1	0.7512
p.P35R	DO229031	LICA	ICGC	VTPVRS	DEG_SCF_FBW7_1	0.7512
p.P35R	DO231061	LUSC	ICGC	VTPVRS	DEG_SCF_FBW7_1	0.7512
p.T34S	DO228627	GACA	ICGC	VTPVRS	DEG_SCF_FBW7_1	0.7116
p.T29M	DO36572	READ	ICGC	VTPVRS	DEG_SCF_FBW7_1	0.2222
p.R40G	ACH-001382	Pancreatic Cancer	CCLE	VTPVRS	DEG_SCF_FBW7_1	0.2778
p.R40G	ACH-001419	Breast Cancer	CCLE	VTPVRS	DEG_SCF_FBW7_1	0.2778
p.P35S	ACH-001494	Bile Duct Cancer	CCLE	VTPVRS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0C264	Uncharacterized serine/threonine-protein kinase SBK3	DEG_SCF_FBW7_1	33:38	VTPVRS	FBXW7	0.7829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons