DegronMD

Uniprot ID: Q9NZJ0

Source protein: Denticleless protein homolog

Source gene: DTL

Class: DEG_SCF_FBW7_1

Location: 505:512

E3 ligase: FBXW7

DEGRON score: 0.9916

ASA_SCORE: 73.7625

COIL: 0.8029

CONS_SCORE: 0.3813

DSS_SCORE: 0.5725

HELIX: 0.0423

FCONS_SCORE: 0.941

RIG_SCORE: 0.6377

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R507Q	TCGA-E6-A1LX	UCEC	TCGA	VTRTPSSS	DEG_SCF_FBW7_1	0.6218
p.F497L	TCGA-LT-A5Z6	BLCA	TCGA	VTRTPSSS	DEG_SCF_FBW7_1	0.1111
p.S510P	TCGA-ZB-A966	THYM	TCGA	VTRTPSSS	DEG_SCF_FBW7_1	0.6752
p.R508I	DO224590	BRCA	ICGC	VTRTPSSS	DEG_SCF_FBW7_1	0.8102
p.R508I	DO1018	BRCA	ICGC	VTRTPSSS	DEG_SCF_FBW7_1	0.8102
p.R508K	DO49916	CESC	ICGC	VTRTPSSS	DEG_SCF_FBW7_1	0.7237
p.R506K	DO49918	CESC	ICGC	VTRTPSSS	DEG_SCF_FBW7_1	0.7237
p.V521L	DO229037	LICA	ICGC	VTRTPSSS	DEG_SCF_FBW7_1	0.0833
p.R512S	DO27240	LUSC	ICGC	VTRTPSSS	DEG_SCF_FBW7_1	0.7427
p.K510R	DO47789	STAD	ICGC	VTRTPSSS	DEG_SCF_FBW7_1	0.7237
p.K522Q	Hep_3B2_1-7	NS	COSMIC	VTRTPSSS	DEG_SCF_FBW7_1	0.0556
p.Q498P	EMC-BAC-2	lung	COSMIC	VTRTPSSS	DEG_SCF_FBW7_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZJ0	Denticleless protein homolog	DEG_SCF_FBW7_1	505:512	VTRTPSSS	FBXW7	0.9916	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons