DegronMD

Uniprot ID: Q99612

Source protein: Krueppel-like factor 6

Source gene: KLF6

Class: DEG_SCF_FBW7_1

Location: 144:151

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 71.4375

COIL: 0.9398

CONS_SCORE: 0.7473

DSS_SCORE: 0.6225

HELIX: 0.0116

FCONS_SCORE: 1.487

RIG_SCORE: 0.5817

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P149Q	DO233760	GACA	ICGC	VTSTPPSS	DEG_SCF_FBW7_1	0.5924
p.S142Y	DO228245	LICA	ICGC	VTSTPPSS	DEG_SCF_FBW7_1	0.2778
p.P158T	DO229036	LICA	ICGC	VTSTPPSS	DEG_SCF_FBW7_1	0.1389
p.S146Y	SIDM01051	Ovarian Carcinoma	GDSC	VTSTPPSS	DEG_SCF_FBW7_1	0.6009
p.S146Y	ACH-000936	Ovarian Cancer	CCLE	VTSTPPSS	DEG_SCF_FBW7_1	0.6009
p.S146Y	EFO-27	ovary	COSMIC	VTSTPPSS	DEG_SCF_FBW7_1	0.6009

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99612	Krueppel-like factor 6	DEG_SCF_FBW7_1	144:151	VTSTPPSS	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons