DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VTTPSPS
Uniprot ID:
Q2M2H8
Source protein:
Probable maltase-glucoamylase 2
Source gene:
MGAM2
Class:
DEG_SCF_FBW7_1
Location:
2269:2275
E3 ligase:
FBXW7
DEGRON score:
0.942
ASA_SCORE:
75.4143
COIL:
0.7687
CONS_SCORE:
0
DSS_SCORE:
0.5178
HELIX:
0.0154
FCONS_SCORE:
0
RIG_SCORE:
0.6787
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MGAM2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTTPSPS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q2M2H8
Probable maltase-glucoamylase 2
DEG_SCF_FBW7_1
2269:2275
VTTPSPS
FBXW7
0.942
More...