DegronMD

Uniprot ID: Q15029

Source protein: 116 kDa U5 small nuclear ribonucleoprotein component

Source gene: EFTUD2

Class: LIG_APCC_ABBA_1

Location: 57:62

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9936

ASA_SCORE: 70.8333

COIL: 0.4363

CONS_SCORE: 0.4655

DSS_SCORE: 0.6099

HELIX: 0.1147

FCONS_SCORE: 1.3652

RIG_SCORE: 0.7638

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D50N	TCGA-CM-6674	COAD	TCGA	VVLHED	LIG_APCC_ABBA_1	0.1389
p.D50N	DO10092	COAD	ICGC	VVLHED	LIG_APCC_ABBA_1	0.1389
p.H48Y	TCGA-DA-A1I8	SKCM	TCGA	VVLHED	LIG_APCC_ABBA_1	0.0833
p.H48Y	DO37424	SKCM	ICGC	VVLHED	LIG_APCC_ABBA_1	0.0833
p.E70K	TCGA-K7-A6G5	LIHC	TCGA	VVLHED	LIG_APCC_ABBA_1	0.1111
p.E70K	DO48602	LIHC	ICGC	VVLHED	LIG_APCC_ABBA_1	0.1111
p.D49N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VVLHED	LIG_APCC_ABBA_1	0.1111
p.D49N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VVLHED	LIG_APCC_ABBA_1	0.1111
p.D49N	ACH-000995	Leukemia	CCLE	VVLHED	LIG_APCC_ABBA_1	0.1111
p.K66T	SNU-81	large_intestine	COSMIC	VVLHED	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15029	116 kDa U5 small nuclear ribonucleoprotein component	LIG_APCC_ABBA_1	57:62	VVLHED	APC,CDC20,FZR1	0.9936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons