DegronMD

Uniprot ID: Q96I82

Source protein: Kazal-type serine protease inhibitor domain-containing protein 1

Source gene: KAZALD1

Class: DEG_SCF_FBW7_1

Location: 21:28

E3 ligase: FBXW7

DEGRON score: 0.6986

ASA_SCORE: 76.5375

COIL: 0.7348

CONS_SCORE: 0.2833

DSS_SCORE: 0.1913

HELIX: 0.1599

FCONS_SCORE: 0.801

RIG_SCORE: 0.7618

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A12T	TCGA-EO-A22U	UCEC	TCGA	VVLTPPPT	DEG_SCF_FBW7_1	0.0833
p.A12T	DO43755	UCEC	ICGC	VVLTPPPT	DEG_SCF_FBW7_1	0.0833
p.V15L	DO228396	MALY	ICGC	VVLTPPPT	DEG_SCF_FBW7_1	0.1667
p.T24A	DO229275	THCA	ICGC	VVLTPPPT	DEG_SCF_FBW7_1	0.7139
p.T24P	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VVLTPPPT	DEG_SCF_FBW7_1	0.7031
p.V15M	ACH-001190	Skin Cancer	CCLE	VVLTPPPT	DEG_SCF_FBW7_1	0.1667
p.L16F	ACH-001538	Bile Duct Cancer	CCLE	VVLTPPPT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96I82	Kazal-type serine protease inhibitor domain-containing protein 1	DEG_SCF_FBW7_1	21:28	VVLTPPPT	FBXW7	0.6986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons