DegronMD

Uniprot ID: Q15831

Source protein: Serine/threonine-protein kinase STK11

Source gene: STK11

Class: LIG_APCC_ABBA_1

Location: 337:342

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6169

ASA_SCORE: 35.2

COIL: 0.0482

CONS_SCORE: 0.4519

DSS_SCORE: 0.4011

HELIX: 0.9265

FCONS_SCORE: 1.2364

RIG_SCORE: 0.8142

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R333S	TCGA-DI-A1BU	UCEC	TCGA	VVPYLE	LIG_APCC_ABBA_1	0.2222
p.R333S	DO42023	UCEC	ICGC	VVPYLE	LIG_APCC_ABBA_1	0.2222
p.L344M	TCGA-FS-A1ZC	SKCM	TCGA	VVPYLE	LIG_APCC_ABBA_1	0.2778
p.L344M	DO37487	SKCM	ICGC	VVPYLE	LIG_APCC_ABBA_1	0.2778
p.D350E	DO48266	ESCA	ICGC	VVPYLE	LIG_APCC_ABBA_1	0.1111
p.G346V	DO229041	LICA	ICGC	VVPYLE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15831	Serine/threonine-protein kinase STK11	LIG_APCC_ABBA_1	337:342	VVPYLE	APC,CDC20,FZR1	0.6169	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons