DegronMD

Uniprot ID: P98161

Source protein: Polycystin-1

Source gene: PKD1

Class: LIG_APCC_ABBA_1

Location: 2944:2949

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6665

ASA_SCORE: 26.1167

COIL: 0.4762

CONS_SCORE: 0.3986

DSS_SCORE: 0.4657

HELIX: 0.0235

FCONS_SCORE: 1.3588

RIG_SCORE: 0.7444

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H2955Q	TCGA-60-2710	LUSC	TCGA	VYLHSE	LIG_APCC_ABBA_1	0.1667
p.H2955Q	DO26938	LUSC	ICGC	VYLHSE	LIG_APCC_ABBA_1	0.1667
p.V2944A	TCGA-AX-A2HJ	UCEC	TCGA	VYLHSE	LIG_APCC_ABBA_1	0.6936
p.V2944A	DO42105	UCEC	ICGC	VYLHSE	LIG_APCC_ABBA_1	0.6936
p.S2958L	SIDM00060	Ovarian Carcinoma	GDSC	VYLHSE	LIG_APCC_ABBA_1	0.0833
p.H2947N	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	VYLHSE	LIG_APCC_ABBA_1	0.7423
p.H2947N	ACH-002253	Lymphoma	CCLE	VYLHSE	LIG_APCC_ABBA_1	0.7423
p.H2947N	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	VYLHSE	LIG_APCC_ABBA_1	0.7423
p.L2946P	SIDM01608	Endometrial Carcinoma	GDSC	VYLHSE	LIG_APCC_ABBA_1	0.6471
p.L2946P	ACH-000990	Endometrial/Uterine Cancer	CCLE	VYLHSE	LIG_APCC_ABBA_1	0.6471
p.P2938A	SIDM01774	Pancreatic Carcinoma	GDSC	VYLHSE	LIG_APCC_ABBA_1	0.1667
p.P2938A	ACH-000205	Pancreatic Cancer	CCLE	VYLHSE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98161	Polycystin-1	LIG_APCC_ABBA_1	2944:2949	VYLHSE	APC,CDC20,FZR1	0.6665	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons