DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
WKENG
Uniprot ID:
Q6ZUB0
Source protein:
Spermatogenesis-associated protein 31D4
Source gene:
SPATA31D4
Class:
DEG_APCC_KENBOX_2
Location:
425:429
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.981
ASA_SCORE:
106.38
COIL:
0.788
CONS_SCORE:
0.4754
DSS_SCORE:
0.4664
HELIX:
0.0766
FCONS_SCORE:
1.2817
RIG_SCORE:
0.7376
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SPATA31D4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of WKENG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P0C874
Spermatogenesis-associated protein 31D3
DEG_APCC_KENBOX_2
425:429
WKENG
APC,CDC20,FZR1
0.9846
More...
Q6ZUB0
Spermatogenesis-associated protein 31D4
DEG_APCC_KENBOX_2
425:429
WKENG
APC,CDC20,FZR1
0.981
More...