DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
WLR
Uniprot ID:
Q9HCC6
Source protein:
Transcription factor HES-4
Source gene:
HES4
Class:
DEG_APCC_TPR_1
Location:
219:221
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9289
ASA_SCORE:
105.2
COIL:
0.945
CONS_SCORE:
0.3798
DSS_SCORE:
0.9412
HELIX:
0.013
FCONS_SCORE:
0.7804
RIG_SCORE:
0.7944
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with HES4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of WLR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9HCC6
Transcription factor HES-4
DEG_APCC_TPR_1
219:221
WLR
APC,CDC20,FZR1
0.9289
More...