DegronMD

Uniprot ID: Q9GZM7

Source protein: Tubulointerstitial nephritis antigen-like

Source gene: TINAGL1

Class: DEG_APCC_DBOX_1

Location: 2:10

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7574

ASA_SCORE: 80.6444

COIL: 0.2369

CONS_SCORE: 0.4106

DSS_SCORE: 0.1416

HELIX: 0.7546

FCONS_SCORE: 1.2703

RIG_SCORE: 0.9144

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P13L	DO228338	MALY	ICGC	WRCPLGLLL	DEG_APCC_DBOX_1	0.25
p.A19V	SIDM00434	Plasma Cell Myeloma	GDSC	WRCPLGLLL	DEG_APCC_DBOX_1	0.0833
p.A19V	ACH-000745	Myeloma	CCLE	WRCPLGLLL	DEG_APCC_DBOX_1	0.0833
p.P5S	SIDM01525	Acute Myeloid Leukemia	GDSC	WRCPLGLLL	DEG_APCC_DBOX_1	0.5641
p.R19H	SNU-1040	large_intestine	COSMIC	WRCPLGLLL	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9GZM7	Tubulointerstitial nephritis antigen-like	DEG_APCC_DBOX_1	2:10	WRCPLGLLL	APC,CDC20,FZR1	0.7574	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons