DegronMD

Uniprot ID: P14784

Source protein: Interleukin-2 receptor subunit beta

Source gene: IL2RB

Class: DEG_APCC_DBOX_1

Location: 8:16

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7905

ASA_SCORE: 84.7333

COIL: 0.176

CONS_SCORE: 0.5987

DSS_SCORE: 0.0056

HELIX: 0.8078

FCONS_SCORE: 1.2957

RIG_SCORE: 0.9743

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R9H	TCGA-UB-A7MD	LIHC	TCGA	WRLPLLILL	DEG_APCC_DBOX_1	0.8244
p.R9H	DO52320	LIHC	ICGC	WRLPLLILL	DEG_APCC_DBOX_1	0.8244
p.A2T	DO50815	LIRI	ICGC	WRLPLLILL	DEG_APCC_DBOX_1	0.1667
p.L16H	DO229272	THCA	ICGC	WRLPLLILL	DEG_APCC_DBOX_1	0.6202
p.A2V	DO229208	THCA	ICGC	WRLPLLILL	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14784	Interleukin-2 receptor subunit beta	DEG_APCC_DBOX_1	8:16	WRLPLLILL	APC,CDC20,FZR1	0.7905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons