DegronMD

Uniprot ID: Q02338

Source protein: D-beta-hydroxybutyrate dehydrogenase, mitochondrial

Source gene: BDH1

Class: DEG_APCC_TPR_1

Location: 341:343

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8484

ASA_SCORE: 89.0667

COIL: 0.8143

CONS_SCORE: 0.2319

DSS_SCORE: 0.5156

HELIX: 0.168

FCONS_SCORE: 0.8084

RIG_SCORE: 0.9085

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R343H	DO46877	RECA	ICGC	YIR	DEG_APCC_TPR_1	0.8244
p.D338N	TCGA-AX-A1C9	UCEC	TCGA	YIR	DEG_APCC_TPR_1	0.25
p.D338N	DO43098	UCEC	ICGC	YIR	DEG_APCC_TPR_1	0.25

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02338	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	DEG_APCC_TPR_1	341:343	YIR	APC,CDC20,FZR1	0.8484	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons