DegronMD

Uniprot ID: Q9UEU0

Source protein: Vesicle transport through interaction with t-SNAREs homolog 1B

Source gene: VTI1B

Class: DEG_APCC_DBOX_1

Location: 84:92

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7596

ASA_SCORE: 74.7111

COIL: 0.0221

CONS_SCORE: 0.466

DSS_SCORE: 0.432

HELIX: 0.9774

FCONS_SCORE: 1.2603

RIG_SCORE: 0.7766

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R85L	TCGA-BQ-7044	KIRP	TCGA	YRKDLAKLH	DEG_APCC_DBOX_1	0.8428
p.R85L	DO20942	KIRP	ICGC	YRKDLAKLH	DEG_APCC_DBOX_1	0.8428
p.R82Q	TCGA-D1-A16X	UCEC	TCGA	YRKDLAKLH	DEG_APCC_DBOX_1	0.2778
p.R82Q	TCGA-D1-A17Q	UCEC	TCGA	YRKDLAKLH	DEG_APCC_DBOX_1	0.2778
p.R82Q	DO229253	THCA	ICGC	YRKDLAKLH	DEG_APCC_DBOX_1	0.2778
p.R82Q	DO41903	UCEC	ICGC	YRKDLAKLH	DEG_APCC_DBOX_1	0.2778
p.R82Q	DO41799	UCEC	ICGC	YRKDLAKLH	DEG_APCC_DBOX_1	0.2778
p.A102T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	YRKDLAKLH	DEG_APCC_DBOX_1	0.0556
p.A102T	ACH-002256	Leukemia	CCLE	YRKDLAKLH	DEG_APCC_DBOX_1	0.0556
p.A102T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	YRKDLAKLH	DEG_APCC_DBOX_1	0.0556
p.A89T	SIDM00674	Non-Cancerous	GDSC	YRKDLAKLH	DEG_APCC_DBOX_1	0.6028
p.A89T	SIDM00675	Breast Carcinoma	GDSC	YRKDLAKLH	DEG_APCC_DBOX_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UEU0	Vesicle transport through interaction with t-SNAREs homolog 1B	DEG_APCC_DBOX_1	84:92	YRKDLAKLH	APC,CDC20,FZR1	0.7596	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons