DegronMD - A0AUZ9(KANSL1L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V209A	TCGA-B5-A1MR	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.5825
p.V209A	DO41758	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.5825
p.K198N	TCGA-BR-8680	STAD	TCGA	PVSSS	DEG_SPOP_SBC_1	208:212	Mutation substituting flanking lysine	0.1667
p.K198N	TCGA-F5-6814	READ	TCGA	PVSSS	DEG_SPOP_SBC_1	208:212	Mutation substituting flanking lysine	0.1667
p.K198N	DO36556	READ	ICGC	PVSSS	DEG_SPOP_SBC_1	208:212	Mutation substituting flanking lysine	0.1667
p.K198N	DO47769	STAD	ICGC	PVSSS	DEG_SPOP_SBC_1	208:212	Mutation substituting flanking lysine	0.1667
p.S46F	TCGA-FR-A726	SKCM	TCGA	PTPEPT	DEG_SCF_FBW7_1	52:57	Mutation rewiring degron network	0.1667
p.S46F	DO48665	SKCM	ICGC	PTPEPT	DEG_SCF_FBW7_1	52:57	Mutation rewiring degron network	0.1667
p.S46F	ACH-002396	Bone Cancer	CCLE	PTPEPT	DEG_SCF_FBW7_1	52:57	Mutation rewiring degron network	0.1667
p.S46F	Sarc9371	bone	COSMIC	PTPEPT	DEG_SCF_FBW7_1	52:57	Mutation rewiring degron network	0.1667
p.H221R	TCGA-NJ-A4YQ	LUAD	TCGA	PVSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0833
p.H221R	DO218944	LUAD	ICGC	PVSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0833
p.P202L	SIDM00084	Glioblastoma	GDSC	PVSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1667
p.P202L	SIDM01203	Other Solid Cancers	GDSC	PVSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1667
p.P202L	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1667
p.P202L	SIDM00779	Colorectal Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1667
p.P202L	SIDM00817	Kidney Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1667
p.P202L	SIDM00752	Non-Cancerous	GDSC	PVSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1667
p.P202L	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1667
p.P202L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PVSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1667
p.P202L	SIDM01105	Melanoma	GDSC	PVSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1667
p.A222T	SIDM01148	Plasma Cell Myeloma	GDSC	PVSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.0556
p.M48I	ACH-000698	Lung Cancer	CCLE	PTPEPT	DEG_SCF_FBW7_1	52:57	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KANSL1L

UniProt ID: A0AUZ9

Entrez ID: 151050

Protein name: KAT8 regulatory NSL complex subunit 1-like protein (MSL1v2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KANSL1L in