DegronMD

Uniprot ID: A0AUZ9

Source protein: KAT8 regulatory NSL complex subunit 1-like protein

Source gene: KANSL1L

Class: DEG_SCF_FBW7_1

Location: 52:57

E3 ligase: FBXW7

DEGRON score: 0.9958

ASA_SCORE: 75.9167

COIL: 0.862

CONS_SCORE: 0.3715

DSS_SCORE: 0.423

HELIX: 0.0885

FCONS_SCORE: 1.082

RIG_SCORE: 0.7217

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S46F	TCGA-FR-A726	SKCM	TCGA	PTPEPT	DEG_SCF_FBW7_1	0.1667
p.S46F	DO48665	SKCM	ICGC	PTPEPT	DEG_SCF_FBW7_1	0.1667
p.S46F	ACH-002396	Bone Cancer	CCLE	PTPEPT	DEG_SCF_FBW7_1	0.1667
p.S46F	Sarc9371	bone	COSMIC	PTPEPT	DEG_SCF_FBW7_1	0.1667
p.M48I	ACH-000698	Lung Cancer	CCLE	PTPEPT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AUZ9	KAT8 regulatory NSL complex subunit 1-like protein	DEG_SCF_FBW7_1	52:57	PTPEPT	FBXW7	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons