DegronMD - A0AV02(SLC12A8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S542R	TCGA-66-2787	LUSC	TCGA	TYGEQLVPEL	DEG_COP1_1	550:559	Mutation rewiring degron network	0.1111
p.E548K	TCGA-85-A4QQ	LUSC	TCGA	TYGEQLVPEL	DEG_COP1_1	550:559	Mutation rewiring degron network	0.2778
p.Q554K	TCGA-AA-A02R	COAD	TCGA	TYGEQLVPEL	DEG_COP1_1	550:559	Mutation altering degron motif	0.5833
p.Q554K	TCGA-AX-A05Z	UCEC	TCGA	TYGEQLVPEL	DEG_COP1_1	550:559	Mutation altering degron motif	0.5833
p.Q554K	DO40884	UCEC	ICGC	TYGEQLVPEL	DEG_COP1_1	550:559	Mutation altering degron motif	0.5833
p.Q562K	TCGA-D3-A2JC	SKCM	TCGA	TYGEQLVPEL	DEG_COP1_1	550:559	Mutation rewiring degron network	0.25
p.Q562K	DO47578	SKCM	ICGC	TYGEQLVPEL	DEG_COP1_1	550:559	Mutation rewiring degron network	0.25
p.Q562H	TCGA-F5-6814	READ	TCGA	TYGEQLVPEL	DEG_COP1_1	550:559	Mutation rewiring degron network	0.25
p.S540F	TCGA-K1-A3PN	SARC	TCGA	TYGEQLVPEL	DEG_COP1_1	550:559	Mutation rewiring degron network	0.0556
p.S540F	DO220185	SARC	ICGC	TYGEQLVPEL	DEG_COP1_1	550:559	Mutation rewiring degron network	0.0556
p.D569V	DO227999	COCA	ICGC	TYGEQLVPEL	DEG_COP1_1	550:559	Mutation rewiring degron network	0.0556
p.D569V	SIDM00292	Small Cell Lung Carcinoma	GDSC	TYGEQLVPEL	DEG_COP1_1	550:559	Mutation rewiring degron network	0.0556
p.D569V	SIDM00502	B-Lymphoblastic Leukemia	GDSC	TYGEQLVPEL	DEG_COP1_1	550:559	Mutation rewiring degron network	0.0556
p.D569V	SIDM01432	Kidney Carcinoma	GDSC	TYGEQLVPEL	DEG_COP1_1	550:559	Mutation rewiring degron network	0.0556
p.D569V	SIDM00162	Biliary Tract Carcinoma	GDSC	TYGEQLVPEL	DEG_COP1_1	550:559	Mutation rewiring degron network	0.0556
p.S563L	SIDM01696	Mesothelioma	GDSC	TYGEQLVPEL	DEG_COP1_1	550:559	Mutation rewiring degron network	0.2222
p.S563L	ACH-000645	Lung Cancer	CCLE	TYGEQLVPEL	DEG_COP1_1	550:559	Mutation rewiring degron network	0.2222

Kaplan plot for SLC12A8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC12A8

UniProt ID: A0AV02

Entrez ID: 84561

Protein name: Solute carrier family 12 member 8 (Cation-chloride cotransporter 9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC12A8 in