DegronMD

Uniprot ID: A0AV02

Source protein: Solute carrier family 12 member 8

Source gene: SLC12A8

Class: DEG_COP1_1

Location: 550:559

E3 ligase: COP1

DEGRON score: 0.8746

ASA_SCORE: 82.76

COIL: 0.6897

CONS_SCORE: 0.1209

DSS_SCORE: 0.6049

HELIX: 0.1279

FCONS_SCORE: 0.8807

RIG_SCORE: 0.7403

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S542R	TCGA-66-2787	LUSC	TCGA	TYGEQLVPEL	DEG_COP1_1	0.1111
p.E548K	TCGA-85-A4QQ	LUSC	TCGA	TYGEQLVPEL	DEG_COP1_1	0.2778
p.Q554K	TCGA-AA-A02R	COAD	TCGA	TYGEQLVPEL	DEG_COP1_1	0.5833
p.Q554K	TCGA-AX-A05Z	UCEC	TCGA	TYGEQLVPEL	DEG_COP1_1	0.5833
p.Q554K	DO40884	UCEC	ICGC	TYGEQLVPEL	DEG_COP1_1	0.5833
p.Q562K	TCGA-D3-A2JC	SKCM	TCGA	TYGEQLVPEL	DEG_COP1_1	0.25
p.Q562K	DO47578	SKCM	ICGC	TYGEQLVPEL	DEG_COP1_1	0.25
p.Q562H	TCGA-F5-6814	READ	TCGA	TYGEQLVPEL	DEG_COP1_1	0.25
p.S540F	TCGA-K1-A3PN	SARC	TCGA	TYGEQLVPEL	DEG_COP1_1	0.0556
p.S540F	DO220185	SARC	ICGC	TYGEQLVPEL	DEG_COP1_1	0.0556
p.D569V	DO227999	COCA	ICGC	TYGEQLVPEL	DEG_COP1_1	0.0556
p.D569V	SIDM00292	Small Cell Lung Carcinoma	GDSC	TYGEQLVPEL	DEG_COP1_1	0.0556
p.D569V	SIDM00502	B-Lymphoblastic Leukemia	GDSC	TYGEQLVPEL	DEG_COP1_1	0.0556
p.D569V	SIDM01432	Kidney Carcinoma	GDSC	TYGEQLVPEL	DEG_COP1_1	0.0556
p.D569V	SIDM00162	Biliary Tract Carcinoma	GDSC	TYGEQLVPEL	DEG_COP1_1	0.0556
p.S563L	SIDM01696	Mesothelioma	GDSC	TYGEQLVPEL	DEG_COP1_1	0.2222
p.S563L	ACH-000645	Lung Cancer	CCLE	TYGEQLVPEL	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AV02	Solute carrier family 12 member 8	DEG_COP1_1	550:559	TYGEQLVPEL	COP1	0.8746	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons