DegronMD - A0PJW8(DAPL1)

DAPL1

Please click HERE for better display.

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A88D	TCGA-CA-6717	COAD	TCGA	PTPALE	DEG_SCF_FBW7_2	85:90	Mutation altering degron motif	0.6682
p.A88D	DO8264	COAD	ICGC	PTPALE	DEG_SCF_FBW7_2	85:90	Mutation altering degron motif	0.6682
p.A88V	TCGA-VQ-A91D	STAD	TCGA	PTPALE	DEG_SCF_FBW7_2	85:90	Mutation altering degron motif	0.5825
p.A88V	DO51783	STAD	ICGC	PTPALE	DEG_SCF_FBW7_2	85:90	Mutation altering degron motif	0.5825
p.S95N	DO228371	MALY	ICGC	PTPALE	DEG_SCF_FBW7_2	85:90	Mutation rewiring degron network	0.1944
p.R77K	DO220883	MELA	ICGC	PTPALE	DEG_SCF_FBW7_2	85:90	Mutation blocking phosphorylation signal	0.5556
p.V93D	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	PTPALE	DEG_SCF_FBW7_2	85:90	Mutation rewiring degron network	0.25
p.R97S	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	PTPALE	DEG_SCF_FBW7_2	85:90	Mutation rewiring degron network	0.1389
p.R97S	ACH-002337	Lung Cancer	CCLE	PTPALE	DEG_SCF_FBW7_2	85:90	Mutation rewiring degron network	0.1389
p.G75V	ACH-000393	Liver Cancer	CCLE	PTPALE	DEG_SCF_FBW7_2	85:90	Mutation rewiring degron network	0.0556
p.V76A	ACH-000620	Liver Cancer	CCLE	PTPALE	DEG_SCF_FBW7_2	85:90	Mutation rewiring degron network	0.0833
p.V76A	ACH-000955	Colon/Colorectal Cancer	CCLE	PTPALE	DEG_SCF_FBW7_2	85:90	Mutation rewiring degron network	0.0833
p.R80M	ACH-001369	Ovarian Cancer	CCLE	PTPALE	DEG_SCF_FBW7_2	85:90	Mutation rewiring degron network	0.1944
p.P75S	ACH-001982	Metastasis	CCLE	PTPALE	DEG_SCF_FBW7_2	85:90	Mutation rewiring degron network	0.0556

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc