DegronMD

Uniprot ID: A0PJW8

Source protein: Death-associated protein-like 1

Source gene: DAPL1

Class: DEG_SCF_FBW7_2

Location: 85:90

E3 ligase: FBXW7

DEGRON score: 0.9911

ASA_SCORE: 79.1167

COIL: 0.8652

CONS_SCORE: 0.7991

DSS_SCORE: 0.3171

HELIX: 0.0715

FCONS_SCORE: 1.1564

RIG_SCORE: 0.7568

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A88D	TCGA-CA-6717	COAD	TCGA	PTPALE	DEG_SCF_FBW7_2	0.6682
p.A88D	DO8264	COAD	ICGC	PTPALE	DEG_SCF_FBW7_2	0.6682
p.A88V	TCGA-VQ-A91D	STAD	TCGA	PTPALE	DEG_SCF_FBW7_2	0.5825
p.A88V	DO51783	STAD	ICGC	PTPALE	DEG_SCF_FBW7_2	0.5825
p.S95N	DO228371	MALY	ICGC	PTPALE	DEG_SCF_FBW7_2	0.1944
p.R77K	DO220883	MELA	ICGC	PTPALE	DEG_SCF_FBW7_2	0.5556
p.V93D	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	PTPALE	DEG_SCF_FBW7_2	0.25
p.R97S	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	PTPALE	DEG_SCF_FBW7_2	0.1389
p.R97S	ACH-002337	Lung Cancer	CCLE	PTPALE	DEG_SCF_FBW7_2	0.1389
p.G75V	ACH-000393	Liver Cancer	CCLE	PTPALE	DEG_SCF_FBW7_2	0.0556
p.V76A	ACH-000620	Liver Cancer	CCLE	PTPALE	DEG_SCF_FBW7_2	0.0833
p.V76A	ACH-000955	Colon/Colorectal Cancer	CCLE	PTPALE	DEG_SCF_FBW7_2	0.0833
p.R80M	ACH-001369	Ovarian Cancer	CCLE	PTPALE	DEG_SCF_FBW7_2	0.1944
p.P75S	ACH-001982	Metastasis	CCLE	PTPALE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0PJW8	Death-associated protein-like 1	DEG_SCF_FBW7_2	85:90	PTPALE	FBXW7	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons