DegronMD - A0PJX4(SHISA3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F178L	TCGA-2W-A8YY	CESC	TCGA	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0833
p.F178L	DO223732	CESC	ICGC	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0833
p.I175T	TCGA-33-4589	LUSC	TCGA	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.I175T	DO26623	LUSC	ICGC	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1667
p.T198N	TCGA-69-7978	LUAD	TCGA	PYTTS	DEG_SPOP_SBC_1	195:199	Mutation altering degron motif	0.7055
p.T198N	DO24920	LUAD	ICGC	PYTTS	DEG_SPOP_SBC_1	195:199	Mutation altering degron motif	0.7055
p.A205D	TCGA-A2-A0YF	BRCA	TCGA	PYTTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.1667
p.A205D	TCGA-A2-A0YF	BRCA	TCGA	PPPY	ITCH	193:196	Mutation rewiring degron network	0.0833
p.A205D	DO1761	BRCA	ICGC	PYTTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.1667
p.A205D	DO1761	BRCA	ICGC	PPPY	ITCH	193:196	Mutation rewiring degron network	0.0833
p.R160Q	TCGA-A5-A1OF	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.R160Q	DO33091	PACA	ICGC	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.R160Q	DO42568	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.R176H	TCGA-AA-3672	COAD	TCGA	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.R176H	DO9010	COAD	ICGC	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.R176H	SIDM00193	Colorectal Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.R176H	ACH-000991	Colon/Colorectal Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.R176H	SNU-81	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.L204M	TCGA-B5-A1MX	UCEC	TCGA	PYTTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.1944
p.L204M	TCGA-B5-A1MX	UCEC	TCGA	PPPY	ITCH	193:196	Mutation rewiring degron network	0.1111
p.L204M	DO41999	UCEC	ICGC	PYTTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.1944
p.L204M	DO41999	UCEC	ICGC	PPPY	ITCH	193:196	Mutation rewiring degron network	0.1111
p.C187F	TCGA-D6-6826	HNSC	TCGA	PYTTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.1111
p.C187F	TCGA-D6-6826	HNSC	TCGA	PPPY	ITCH	193:196	Mutation rewiring degron network	0.1667
p.C187F	DO15543	HNSC	ICGC	PYTTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.1111
p.C187F	DO15543	HNSC	ICGC	PPPY	ITCH	193:196	Mutation rewiring degron network	0.1667
p.S179F	TCGA-FR-A726	SKCM	TCGA	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.S179F	DO220891	MELA	ICGC	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.S179F	DO48665	SKCM	ICGC	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.P193L	TCGA-GU-A763	BLCA	TCGA	PPPY	ITCH	193:196	Mutation altering degron motif	0.7582
p.P193L	DO51888	BLCA	ICGC	PPPY	ITCH	193:196	Mutation altering degron motif	0.7582
p.R160W	DO222955	BTCA	ICGC	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.A157P	DO223048	ESCA	ICGC	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1111
p.A205S	DO229015	LICA	ICGC	PYTTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.1667
p.A205S	DO229015	LICA	ICGC	PPPY	ITCH	193:196	Mutation rewiring degron network	0.0833
p.R160G	DO224563	LUSC	ICGC	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1944
p.G186S	SIDM00845	Burkitt's Lymphoma	GDSC	PYTTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.0833
p.G186S	SIDM00845	Burkitt's Lymphoma	GDSC	PPPY	ITCH	193:196	Mutation rewiring degron network	0.1389
p.P155T	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.P155T	ACH-000638	Lung Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.P155T	NCI-H441	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.H200R	SIDM00792	Small Cell Lung Carcinoma	GDSC	PYTTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.3056
p.H200R	SIDM00792	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	193:196	Mutation rewiring degron network	0.2222
p.H200R	ACH-002170	Lung Cancer	CCLE	PYTTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.3056
p.H200R	ACH-002170	Lung Cancer	CCLE	PPPY	ITCH	193:196	Mutation rewiring degron network	0.2222
p.H200R	NCI-H1688	lung	COSMIC	PYTTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.3056
p.H200R	NCI-H1688	lung	COSMIC	PPPY	ITCH	193:196	Mutation rewiring degron network	0.2222
p.G173S	ACH-000593	Bladder Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.L188P	ACH-000898	Gastric Cancer	CCLE	PYTTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.1389
p.L188P	ACH-000898	Gastric Cancer	CCLE	PPPY	ITCH	193:196	Mutation rewiring degron network	0.1944
p.S163N	ACH-001061	Colon/Colorectal Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2778
p.A157V	ACH-002023	Colon/Colorectal Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHISA3

UniProt ID: A0PJX4

Entrez ID: 152573

Protein name: Protein shisa-3 homolog

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHISA3 in