DegronMD

Uniprot ID: A0PJX4

Source protein: Protein shisa-3 homolog

Source gene: SHISA3

Class: DEG_SPOP_SBC_1

Location: 195:199

E3 ligase: SPOP

DEGRON score: 0.7875

ASA_SCORE: 79.84

COIL: 0.884

CONS_SCORE: 0.5965

DSS_SCORE: 0.4932

HELIX: 0.0566

FCONS_SCORE: 1.0549

RIG_SCORE: 0.6461

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T198N	TCGA-69-7978	LUAD	TCGA	PYTTS	DEG_SPOP_SBC_1	0.7055
p.T198N	DO24920	LUAD	ICGC	PYTTS	DEG_SPOP_SBC_1	0.7055
p.A205D	TCGA-A2-A0YF	BRCA	TCGA	PYTTS	DEG_SPOP_SBC_1	0.1667
p.A205D	DO1761	BRCA	ICGC	PYTTS	DEG_SPOP_SBC_1	0.1667
p.L204M	TCGA-B5-A1MX	UCEC	TCGA	PYTTS	DEG_SPOP_SBC_1	0.1944
p.L204M	DO41999	UCEC	ICGC	PYTTS	DEG_SPOP_SBC_1	0.1944
p.C187F	TCGA-D6-6826	HNSC	TCGA	PYTTS	DEG_SPOP_SBC_1	0.1111
p.C187F	DO15543	HNSC	ICGC	PYTTS	DEG_SPOP_SBC_1	0.1111
p.A205S	DO229015	LICA	ICGC	PYTTS	DEG_SPOP_SBC_1	0.1667
p.G186S	SIDM00845	Burkitt's Lymphoma	GDSC	PYTTS	DEG_SPOP_SBC_1	0.0833
p.H200R	SIDM00792	Small Cell Lung Carcinoma	GDSC	PYTTS	DEG_SPOP_SBC_1	0.3056
p.H200R	ACH-002170	Lung Cancer	CCLE	PYTTS	DEG_SPOP_SBC_1	0.3056
p.H200R	NCI-H1688	lung	COSMIC	PYTTS	DEG_SPOP_SBC_1	0.3056
p.L188P	ACH-000898	Gastric Cancer	CCLE	PYTTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94776	Metastasis-associated protein MTA2	DEG_SPOP_SBC_1	436:440	PYTTS	SPOP	0.9933	More...
Q9BZ29	Dedicator of cytokinesis protein 9	DEG_SPOP_SBC_1	1236:1240	PYTTS	SPOP	0.9991	More...
A0PJX4	Protein shisa-3 homolog	DEG_SPOP_SBC_1	195:199	PYTTS	SPOP	0.7875	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons