DegronMD - O94776(MTA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A441V	TCGA-06-5416	GBM	TCGA	PYTTS	DEG_SPOP_SBC_1	436:440	Mutation rewiring degron network	0.3056
p.S433T	TCGA-19-1386	GBM	TCGA	PYTTS	DEG_SPOP_SBC_1	436:440	Mutation blocking phosphorylation signal	0.6944
p.D523Y	TCGA-AA-3977	COAD	TCGA	PKTPRGT	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.0833
p.S433N	TCGA-B0-4712	KIRC	TCGA	PYTTS	DEG_SPOP_SBC_1	436:440	Mutation blocking phosphorylation signal	0.6944
p.A441T	TCGA-B5-A11E	UCEC	TCGA	PYTTS	DEG_SPOP_SBC_1	436:440	Mutation rewiring degron network	0.3056
p.A526V	TCGA-CM-4743	COAD	TCGA	PKTPRGT	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.1667
p.S548F	TCGA-CN-4730	HNSC	TCGA	PKTPRGT	DEG_SCF_FBW7_1	532:538	Mutation blocking phosphorylation signal	0.5
p.N450S	TCGA-CR-5247	HNSC	TCGA	PYTTS	DEG_SPOP_SBC_1	436:440	Mutation rewiring degron network	0.0556
p.P535S	TCGA-EE-A29M	SKCM	TCGA	PKTPRGT	DEG_SCF_FBW7_1	532:538	Mutation altering degron motif	0.6752
p.A526S	TCGA-MP-A4TE	LUAD	TCGA	PKTPRGT	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.1667
p.P436L	TCGA-S5-A6DX	BLCA	TCGA	PYTTS	DEG_SPOP_SBC_1	436:440	Mutation altering degron motif	0.7582
p.S435Y	TCGA-S5-A6DX	BLCA	TCGA	PYTTS	DEG_SPOP_SBC_1	436:440	Mutation blocking phosphorylation signal	0.75
p.R536Q	TCGA-UY-A8OB	BLCA	TCGA	PKTPRGT	DEG_SCF_FBW7_1	532:538	Mutation altering degron motif	0.6218
p.L450V	DO217864	BTCA	ICGC	PYTTS	DEG_SPOP_SBC_1	436:440	Mutation rewiring degron network	0.0556
p.R444Q	DO8119	COAD	ICGC	PYTTS	DEG_SPOP_SBC_1	436:440	Mutation rewiring degron network	0.2222
p.P431H	DO22237	LGG	ICGC	PYTTS	DEG_SPOP_SBC_1	436:440	Mutation rewiring degron network	0.1944
p.P431H	DO229037	LICA	ICGC	PYTTS	DEG_SPOP_SBC_1	436:440	Mutation rewiring degron network	0.1944
p.A442D	DO229025	LICA	ICGC	PYTTS	DEG_SPOP_SBC_1	436:440	Mutation rewiring degron network	0.2778
p.P541Q	SIDM00373	Endometrial Carcinoma	GDSC	PKTPRGT	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.25
p.I542T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PKTPRGT	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.2222
p.I542T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PKTPRGT	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.2222
p.P431L	ACH-000899	Skin Cancer	CCLE	PYTTS	DEG_SPOP_SBC_1	436:440	Mutation rewiring degron network	0.1944

Kaplan plot for MTA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTA2

UniProt ID: O94776

Entrez ID: 9219

Protein name: Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTA2 in