DegronMD

Uniprot ID: O94776

Source protein: Metastasis-associated protein MTA2

Source gene: MTA2

Class: DEG_SCF_FBW7_1

Location: 532:538

E3 ligase: FBXW7

DEGRON score: 0.9932

ASA_SCORE: 96.5571

COIL: 0.9396

CONS_SCORE: 0.5789

DSS_SCORE: 0.649

HELIX: 0.0219

FCONS_SCORE: 1.27

RIG_SCORE: 0.6785

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D523Y	TCGA-AA-3977	COAD	TCGA	PKTPRGT	DEG_SCF_FBW7_1	0.0833
p.A526V	TCGA-CM-4743	COAD	TCGA	PKTPRGT	DEG_SCF_FBW7_1	0.1667
p.S548F	TCGA-CN-4730	HNSC	TCGA	PKTPRGT	DEG_SCF_FBW7_1	0.5
p.P535S	TCGA-EE-A29M	SKCM	TCGA	PKTPRGT	DEG_SCF_FBW7_1	0.6752
p.A526S	TCGA-MP-A4TE	LUAD	TCGA	PKTPRGT	DEG_SCF_FBW7_1	0.1667
p.R536Q	TCGA-UY-A8OB	BLCA	TCGA	PKTPRGT	DEG_SCF_FBW7_1	0.6218
p.P541Q	SIDM00373	Endometrial Carcinoma	GDSC	PKTPRGT	DEG_SCF_FBW7_1	0.25
p.I542T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PKTPRGT	DEG_SCF_FBW7_1	0.2222
p.I542T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PKTPRGT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94776	Metastasis-associated protein MTA2	DEG_SCF_FBW7_1	532:538	PKTPRGT	FBXW7	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons