DegronMD

Uniprot ID: O94776

Source protein: Metastasis-associated protein MTA2

Source gene: MTA2

Class: DEG_SPOP_SBC_1

Location: 436:440

E3 ligase: SPOP

DEGRON score: 0.9933

ASA_SCORE: 81.26

COIL: 0.844

CONS_SCORE: 0.4605

DSS_SCORE: 0.5514

HELIX: 0.1104

FCONS_SCORE: 0.9088

RIG_SCORE: 0.6947

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A441V	TCGA-06-5416	GBM	TCGA	PYTTS	DEG_SPOP_SBC_1	0.3056
p.S433T	TCGA-19-1386	GBM	TCGA	PYTTS	DEG_SPOP_SBC_1	0.6944
p.S433N	TCGA-B0-4712	KIRC	TCGA	PYTTS	DEG_SPOP_SBC_1	0.6944
p.A441T	TCGA-B5-A11E	UCEC	TCGA	PYTTS	DEG_SPOP_SBC_1	0.3056
p.N450S	TCGA-CR-5247	HNSC	TCGA	PYTTS	DEG_SPOP_SBC_1	0.0556
p.P436L	TCGA-S5-A6DX	BLCA	TCGA	PYTTS	DEG_SPOP_SBC_1	0.7582
p.S435Y	TCGA-S5-A6DX	BLCA	TCGA	PYTTS	DEG_SPOP_SBC_1	0.75
p.L450V	DO217864	BTCA	ICGC	PYTTS	DEG_SPOP_SBC_1	0.0556
p.R444Q	DO8119	COAD	ICGC	PYTTS	DEG_SPOP_SBC_1	0.2222
p.P431H	DO22237	LGG	ICGC	PYTTS	DEG_SPOP_SBC_1	0.1944
p.P431H	DO229037	LICA	ICGC	PYTTS	DEG_SPOP_SBC_1	0.1944
p.A442D	DO229025	LICA	ICGC	PYTTS	DEG_SPOP_SBC_1	0.2778
p.P431L	ACH-000899	Skin Cancer	CCLE	PYTTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94776	Metastasis-associated protein MTA2	DEG_SPOP_SBC_1	436:440	PYTTS	SPOP	0.9933	More...
Q9BZ29	Dedicator of cytokinesis protein 9	DEG_SPOP_SBC_1	1236:1240	PYTTS	SPOP	0.9991	More...
A0PJX4	Protein shisa-3 homolog	DEG_SPOP_SBC_1	195:199	PYTTS	SPOP	0.7875	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons