DegronMD - Q9BZ29(DOCK9)

DOCK9

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1234Y	TCGA-AN-A046	BRCA	TCGA	PYTTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.2778
p.P1235S	TCGA-AP-A059	UCEC	TCGA	PYTTS	DEG_SPOP_SBC_1	1236:1240	Mutation blocking phosphorylation signal	0.75
p.P1235L	TCGA-D3-A3MR	SKCM	TCGA	PYTTS	DEG_SPOP_SBC_1	1236:1240	Mutation blocking phosphorylation signal	0.75
p.G1231D	TCGA-EO-A22R	UCEC	TCGA	PYTTS	DEG_SPOP_SBC_1	1236:1240	Mutation blocking phosphorylation signal	0.6389
p.G1231D	DO42713	UCEC	ICGC	PYTTS	DEG_SPOP_SBC_1	1236:1240	Mutation blocking phosphorylation signal	0.6389
p.I1232V	TCGA-EW-A1IZ	BRCA	TCGA	PYTTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.2222
p.I1232V	DO2937	BRCA	ICGC	PYTTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.2222
p.S1246Y	DO1285	BRCA	ICGC	PYTTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1667
p.P1247S	DO48302	ESCA	ICGC	PYTTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1389
p.P1247S	DO41361	UCEC	ICGC	PYTTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1389
p.L1241F	DO15815	HNSC	ICGC	PYTTS	DEG_SPOP_SBC_1	1236:1240	Mutation blocking phosphorylation signal	0.75
p.A1235V	DO46368	OV	ICGC	PYTTS	DEG_SPOP_SBC_1	1236:1240	Mutation blocking phosphorylation signal	0.75
p.P1247L	DO47256	SKCM	ICGC	PYTTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1389
p.L1242I	DO41020	UCEC	ICGC	PYTTS	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc