DegronMD

Uniprot ID: Q9BZ29

Source protein: Dedicator of cytokinesis protein 9

Source gene: DOCK9

Class: DEG_SPOP_SBC_1

Location: 1236:1240

E3 ligase: SPOP

DEGRON score: 0.9991

ASA_SCORE: 69.34

COIL: 0.7914

CONS_SCORE: 0.3352

DSS_SCORE: 0.3868

HELIX: 0.06

FCONS_SCORE: 1.0215

RIG_SCORE: 0.7093

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1234Y	TCGA-AN-A046	BRCA	TCGA	PYTTS	DEG_SPOP_SBC_1	0.2778
p.P1235S	TCGA-AP-A059	UCEC	TCGA	PYTTS	DEG_SPOP_SBC_1	0.75
p.P1235L	TCGA-D3-A3MR	SKCM	TCGA	PYTTS	DEG_SPOP_SBC_1	0.75
p.G1231D	TCGA-EO-A22R	UCEC	TCGA	PYTTS	DEG_SPOP_SBC_1	0.6389
p.G1231D	DO42713	UCEC	ICGC	PYTTS	DEG_SPOP_SBC_1	0.6389
p.I1232V	TCGA-EW-A1IZ	BRCA	TCGA	PYTTS	DEG_SPOP_SBC_1	0.2222
p.I1232V	DO2937	BRCA	ICGC	PYTTS	DEG_SPOP_SBC_1	0.2222
p.S1246Y	DO1285	BRCA	ICGC	PYTTS	DEG_SPOP_SBC_1	0.1667
p.P1247S	DO48302	ESCA	ICGC	PYTTS	DEG_SPOP_SBC_1	0.1389
p.P1247S	DO41361	UCEC	ICGC	PYTTS	DEG_SPOP_SBC_1	0.1389
p.L1241F	DO15815	HNSC	ICGC	PYTTS	DEG_SPOP_SBC_1	0.75
p.A1235V	DO46368	OV	ICGC	PYTTS	DEG_SPOP_SBC_1	0.75
p.P1247L	DO47256	SKCM	ICGC	PYTTS	DEG_SPOP_SBC_1	0.1389
p.L1242I	DO41020	UCEC	ICGC	PYTTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94776	Metastasis-associated protein MTA2	DEG_SPOP_SBC_1	436:440	PYTTS	SPOP	0.9933	More...
Q9BZ29	Dedicator of cytokinesis protein 9	DEG_SPOP_SBC_1	1236:1240	PYTTS	SPOP	0.9991	More...
A0PJX4	Protein shisa-3 homolog	DEG_SPOP_SBC_1	195:199	PYTTS	SPOP	0.7875	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons