DegronMD - A0PJY2(FEZF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A430T	TCGA-05-4382	LUAD	TCGA	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation altering degron motif	0.6028
p.T432K	TCGA-05-4397	LUAD	TCGA	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation altering degron motif	0.7306
p.T432R	TCGA-3P-A9WA	OV	TCGA	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation altering degron motif	0.7876
p.G435A	TCGA-66-2767	LUSC	TCGA	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation altering degron motif	0.6429
p.P441Q	TCGA-86-8674	LUAD	TCGA	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1944
p.P441L	TCGA-AJ-A3OJ	UCEC	TCGA	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1944
p.P433S	TCGA-AP-A051	UCEC	TCGA	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation altering degron motif	0.6752
p.D424N	TCGA-XF-A9SV	BLCA	TCGA	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1944
p.D424N	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1944
p.D424N	ACH-000562	Lung Cancer	CCLE	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1944
p.D424N	HCC-78	lung	COSMIC	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1944
p.R420C	TCGA-YD-A9TA	SKCM	TCGA	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.0833
p.G423D	DO26504	LUSC	ICGC	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1667
p.P443S	SIDM00447	B-Lymphoblastic Leukemia	GDSC	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1389
p.P443S	ACH-000960	Leukemia	CCLE	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1389
p.H423Q	SIDM00999	Bladder Carcinoma	GDSC	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1667
p.H423Q	ACH-000973	Bladder Cancer	CCLE	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1667
p.H423Q	639-V	urinary tract	COSMIC	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.1667
p.R431C	SIDM01664	Prostate Carcinoma	GDSC	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation altering degron motif	0.719
p.R431C	ACH-000952	Prostate Cancer	CCLE	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation altering degron motif	0.719
p.E436K	SIDM01611	Endometrial Carcinoma	GDSC	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation altering degron motif	0.7022
p.E436K	ACH-000996	Endometrial/Uterine Cancer	CCLE	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation altering degron motif	0.7022
p.E440D	ACH-000515	Lung Cancer	CCLE	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.2222
p.E440D	ACH-000988	Endometrial/Uterine Cancer	CCLE	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.2222
p.E440D	ACH-002089	Lung Cancer	CCLE	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.2222
p.E440D	ACH-002189	Kidney Cancer	CCLE	LARTPAGE	DEG_SCF_FBW7_2	429:436	Mutation rewiring degron network	0.2222

Kaplan plot for FEZF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FEZF1

UniProt ID: A0PJY2

Entrez ID: 389549

Protein name: Fez family zinc finger protein 1 (Zinc finger protein 312B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FEZF1 in