DegronMD

Uniprot ID: A0PJY2

Source protein: Fez family zinc finger protein 1

Source gene: FEZF1

Class: DEG_SCF_FBW7_2

Location: 429:436

E3 ligase: FBXW7

DEGRON score: 0.908

ASA_SCORE: 57.6

COIL: 0.7163

CONS_SCORE: 0.3697

DSS_SCORE: 0.7422

HELIX: 0.0744

FCONS_SCORE: 0.707

RIG_SCORE: 0.5492

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A430T	TCGA-05-4382	LUAD	TCGA	LARTPAGE	DEG_SCF_FBW7_2	0.6028
p.T432K	TCGA-05-4397	LUAD	TCGA	LARTPAGE	DEG_SCF_FBW7_2	0.7306
p.T432R	TCGA-3P-A9WA	OV	TCGA	LARTPAGE	DEG_SCF_FBW7_2	0.7876
p.G435A	TCGA-66-2767	LUSC	TCGA	LARTPAGE	DEG_SCF_FBW7_2	0.6429
p.P441Q	TCGA-86-8674	LUAD	TCGA	LARTPAGE	DEG_SCF_FBW7_2	0.1944
p.P441L	TCGA-AJ-A3OJ	UCEC	TCGA	LARTPAGE	DEG_SCF_FBW7_2	0.1944
p.P433S	TCGA-AP-A051	UCEC	TCGA	LARTPAGE	DEG_SCF_FBW7_2	0.6752
p.D424N	TCGA-XF-A9SV	BLCA	TCGA	LARTPAGE	DEG_SCF_FBW7_2	0.1944
p.D424N	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	LARTPAGE	DEG_SCF_FBW7_2	0.1944
p.D424N	ACH-000562	Lung Cancer	CCLE	LARTPAGE	DEG_SCF_FBW7_2	0.1944
p.D424N	HCC-78	lung	COSMIC	LARTPAGE	DEG_SCF_FBW7_2	0.1944
p.R420C	TCGA-YD-A9TA	SKCM	TCGA	LARTPAGE	DEG_SCF_FBW7_2	0.0833
p.G423D	DO26504	LUSC	ICGC	LARTPAGE	DEG_SCF_FBW7_2	0.1667
p.P443S	SIDM00447	B-Lymphoblastic Leukemia	GDSC	LARTPAGE	DEG_SCF_FBW7_2	0.1389
p.P443S	ACH-000960	Leukemia	CCLE	LARTPAGE	DEG_SCF_FBW7_2	0.1389
p.H423Q	SIDM00999	Bladder Carcinoma	GDSC	LARTPAGE	DEG_SCF_FBW7_2	0.1667
p.H423Q	ACH-000973	Bladder Cancer	CCLE	LARTPAGE	DEG_SCF_FBW7_2	0.1667
p.H423Q	639-V	urinary_tract	COSMIC	LARTPAGE	DEG_SCF_FBW7_2	0.1667
p.R431C	SIDM01664	Prostate Carcinoma	GDSC	LARTPAGE	DEG_SCF_FBW7_2	0.719
p.R431C	ACH-000952	Prostate Cancer	CCLE	LARTPAGE	DEG_SCF_FBW7_2	0.719
p.E436K	SIDM01611	Endometrial Carcinoma	GDSC	LARTPAGE	DEG_SCF_FBW7_2	0.7022
p.E436K	ACH-000996	Endometrial/Uterine Cancer	CCLE	LARTPAGE	DEG_SCF_FBW7_2	0.7022
p.E440D	ACH-000515	Lung Cancer	CCLE	LARTPAGE	DEG_SCF_FBW7_2	0.2222
p.E440D	ACH-000988	Endometrial/Uterine Cancer	CCLE	LARTPAGE	DEG_SCF_FBW7_2	0.2222
p.E440D	ACH-002089	Lung Cancer	CCLE	LARTPAGE	DEG_SCF_FBW7_2	0.2222
p.E440D	ACH-002189	Kidney Cancer	CCLE	LARTPAGE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LARTPAGE

Degron related mutations and impact score

Drug responses associated with FEZF1 mutations

All proteins holding degron of LARTPAGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0PJY2	Fez family zinc finger protein 1	DEG_SCF_FBW7_2	429:436	LARTPAGE	FBXW7	0.908	More...