DegronMD - A0PK05(TMEM72)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H223Q	TCGA-AX-A3FT	UCEC	TCGA	KKQVHFE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.7582
p.S234F	TCGA-EE-A29D	SKCM	TCGA	KKQVHFE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.0833
p.E225K	TCGA-EE-A3AF	SKCM	TCGA	KKQVHFE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation altering degron motif	0.7022
p.S215T	TCGA-NC-A5HP	LUSC	TCGA	KKQVHFE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.2222
p.D226Y	TCGA-VS-A9V3	CESC	TCGA	KKQVHFE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.3056
p.D214N	SIDM00484	Thyroid Gland Carcinoma	GDSC	KKQVHFE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1944
p.D214N	SIDM00969	Ovarian Carcinoma	GDSC	KKQVHFE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1944
p.D214N	SIDM00493	Other Solid Cancers	GDSC	KKQVHFE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1944
p.D214N	SIDM00875	Breast Carcinoma	GDSC	KKQVHFE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1944
p.D214N	SIDM00032	Bladder Carcinoma	GDSC	KKQVHFE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1944
p.D214N	SIDM00863	Burkitt's Lymphoma	GDSC	KKQVHFE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1944
p.D214N	SIDM01409	Bladder Carcinoma	GDSC	KKQVHFE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1944
p.D214N	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	KKQVHFE	LIG_APCC_ABBAyCdc20_2	219:225	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons