DegronMD

Uniprot ID: A0PK05

Source protein: Transmembrane protein 72

Source gene: TMEM72

Class: LIG_APCC_ABBAyCdc20_2

Location: 219:225

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8299

ASA_SCORE: 94.4714

COIL: 0.4236

CONS_SCORE: 0.4005

DSS_SCORE: 0.3764

HELIX: 0.4206

FCONS_SCORE: 1.2662

RIG_SCORE: 0.7638

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H223Q	TCGA-AX-A3FT	UCEC	TCGA	KKQVHFE	LIG_APCC_ABBAyCdc20_2	0.7582
p.S234F	TCGA-EE-A29D	SKCM	TCGA	KKQVHFE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E225K	TCGA-EE-A3AF	SKCM	TCGA	KKQVHFE	LIG_APCC_ABBAyCdc20_2	0.7022
p.S215T	TCGA-NC-A5HP	LUSC	TCGA	KKQVHFE	LIG_APCC_ABBAyCdc20_2	0.2222
p.D226Y	TCGA-VS-A9V3	CESC	TCGA	KKQVHFE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D214N	SIDM00484	Thyroid Gland Carcinoma	GDSC	KKQVHFE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D214N	SIDM00969	Ovarian Carcinoma	GDSC	KKQVHFE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D214N	SIDM00493	Other Solid Cancers	GDSC	KKQVHFE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D214N	SIDM00875	Breast Carcinoma	GDSC	KKQVHFE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D214N	SIDM00032	Bladder Carcinoma	GDSC	KKQVHFE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D214N	SIDM00863	Burkitt's Lymphoma	GDSC	KKQVHFE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D214N	SIDM01409	Bladder Carcinoma	GDSC	KKQVHFE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D214N	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	KKQVHFE	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0PK05	Transmembrane protein 72	LIG_APCC_ABBAyCdc20_2	219:225	KKQVHFE	APC,CDC20,FZR1	0.8299	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons