DegronMD - A1A519(FAM170A)

FUNCTION: Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE). {ECO:0000269|PubMed:20162441}.

GO - Biological processes (BP): fertilization [GO:0009566]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription by RNA polymerase II [GO:0006366]

GO - Molecular function (MF): DNA binding [GO:0003677]; metal ion binding [GO:0046872]

GO - Cellular component (CC): nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R51H	NY	bone	COSMIC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.8244
p.S53F	TCGA-C5-A8XJ	CESC	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7982
p.S53F	DO49902	CESC	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7982
p.S55F	TCGA-IH-A3EA	SKCM	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7982
p.S55F	DO222595	MELA	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7982
p.S55F	DO37667	SKCM	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7982
p.V51I	DO51142	PRAD	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7076
p.E56K	TCGA-AA-3984	COAD	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.E56K	TCGA-AA-A00N	COAD	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.E56K	DO9002	COAD	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.E56K	DO9876	COAD	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.E56K	SIDM00660	Colorectal Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.E56K	ACH-000985	Colon/Colorectal Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.E56K	LS-411N	large intestine	COSMIC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.C58R	TCGA-CD-A48A	STAD	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.25
p.C58R	DO47781	STAD	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.25
p.S59C	TCGA-CR-6472	HNSC	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2222
p.S59C	DO15870	HNSC	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2222
p.G47E	TCGA-EB-A3Y7	SKCM	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2222
p.G47E	DO37499	SKCM	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2222

Showing 1 to 20 of 48 entries

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Kaplan plot for FAM170A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM170A

UniProt ID: A1A519

Entrez ID: 340069

Protein name: Protein FAM170A (Zinc finger domain-containing protein) (Zinc finger protein ZNFD)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM170A in