DegronMD - A1A519(FAM170A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R65L	TCGA-44-2659	LUAD	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.R65L	DO23744	LUAD	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.S63Y	TCGA-A5-A2K5	UCEC	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1111
p.S63Y	DO41379	UCEC	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1111
p.V61I	TCGA-A6-2684	COAD	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1667
p.V61I	TCGA-AA-3811	COAD	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1667
p.V61I	TCGA-FP-A9TM	STAD	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1667
p.V61I	DO9074	COAD	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1667
p.V61I	DO10236	COAD	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1667
p.V61I	DO7962	COAD	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1667
p.V61I	DO222332	STAD	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1667
p.V61I	SIDM01296	Esophageal Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1667
p.E56K	TCGA-AA-3984	COAD	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.E56K	TCGA-AA-A00N	COAD	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.E56K	DO9002	COAD	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.E56K	DO9876	COAD	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.E56K	SIDM00660	Colorectal Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.E56K	ACH-000985	Colon/Colorectal Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.E56K	LS-411N	large intestine	COSMIC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.3056
p.G43D	TCGA-AA-A010	COAD	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1111
p.S53F	TCGA-C5-A8XJ	CESC	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7982
p.S53F	DO49902	CESC	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7982
p.C58R	TCGA-CD-A48A	STAD	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.25
p.C58R	DO47781	STAD	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.25
p.S59C	TCGA-CR-6472	HNSC	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2222
p.S59C	DO15870	HNSC	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2222
p.G47E	TCGA-EB-A3Y7	SKCM	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2222
p.G47E	DO37499	SKCM	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2222
p.S55F	TCGA-IH-A3EA	SKCM	TCGA	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7982
p.S55F	DO222595	MELA	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7982
p.S55F	DO37667	SKCM	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7982
p.A41S	DO228976	LICA	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.V51I	DO51142	PRAD	ICGC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.7076
p.S59Y	SIDM00789	Colorectal Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2222
p.S59Y	ACH-000997	Colon/Colorectal Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2222
p.S59Y	HCT-15	large intestine	COSMIC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2222
p.R65H	SIDM00878	Breast Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.R65H	SIDM00534	Colorectal Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.R65H	ACH-000930	Breast Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.R65H	ACH-000986	Colon/Colorectal Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.R65H	HCC1569	breast	COSMIC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.R65H	HT-115	large intestine	COSMIC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.0556
p.G47R	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2222
p.G47R	ACH-000318	Esophageal Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2222
p.G47R	TE-10	oesophagus	COSMIC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.2222
p.R45Q	CP66-MEL	skin	COSMIC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1667
p.S61L	COLO-783	skin	COSMIC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation rewiring degron network	0.1667
p.R51H	NY	bone	COSMIC	VTSTS	DEG_SPOP_SBC_1	51:55	Mutation altering degron motif	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM170A

UniProt ID: A1A519

Entrez ID: 340069

Protein name: Protein FAM170A (Zinc finger domain-containing protein) (Zinc finger protein ZNFD)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM170A in