DegronMD

Uniprot ID: A1A519

Source protein: Protein FAM170A

Source gene: FAM170A

Class: DEG_SPOP_SBC_1

Location: 51:55

E3 ligase: SPOP

DEGRON score: 0.8827

ASA_SCORE: 62.14

COIL: 0.7024

CONS_SCORE: 0.44

DSS_SCORE: 0.3022

HELIX: 0.165

FCONS_SCORE: 1.1149

RIG_SCORE: 0.7514

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R65L	TCGA-44-2659	LUAD	TCGA	VTSTS	DEG_SPOP_SBC_1	0.0556
p.R65L	DO23744	LUAD	ICGC	VTSTS	DEG_SPOP_SBC_1	0.0556
p.S63Y	TCGA-A5-A2K5	UCEC	TCGA	VTSTS	DEG_SPOP_SBC_1	0.1111
p.S63Y	DO41379	UCEC	ICGC	VTSTS	DEG_SPOP_SBC_1	0.1111
p.V61I	TCGA-A6-2684	COAD	TCGA	VTSTS	DEG_SPOP_SBC_1	0.1667
p.V61I	TCGA-AA-3811	COAD	TCGA	VTSTS	DEG_SPOP_SBC_1	0.1667
p.V61I	TCGA-FP-A9TM	STAD	TCGA	VTSTS	DEG_SPOP_SBC_1	0.1667
p.V61I	DO9074	COAD	ICGC	VTSTS	DEG_SPOP_SBC_1	0.1667
p.V61I	DO10236	COAD	ICGC	VTSTS	DEG_SPOP_SBC_1	0.1667
p.V61I	DO7962	COAD	ICGC	VTSTS	DEG_SPOP_SBC_1	0.1667
p.V61I	DO222332	STAD	ICGC	VTSTS	DEG_SPOP_SBC_1	0.1667
p.V61I	SIDM01296	Esophageal Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.1667
p.E56K	TCGA-AA-3984	COAD	TCGA	VTSTS	DEG_SPOP_SBC_1	0.3056
p.E56K	TCGA-AA-A00N	COAD	TCGA	VTSTS	DEG_SPOP_SBC_1	0.3056
p.E56K	DO9002	COAD	ICGC	VTSTS	DEG_SPOP_SBC_1	0.3056
p.E56K	DO9876	COAD	ICGC	VTSTS	DEG_SPOP_SBC_1	0.3056
p.E56K	SIDM00660	Colorectal Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.3056
p.E56K	ACH-000985	Colon/Colorectal Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	0.3056
p.E56K	LS-411N	large_intestine	COSMIC	VTSTS	DEG_SPOP_SBC_1	0.3056
p.G43D	TCGA-AA-A010	COAD	TCGA	VTSTS	DEG_SPOP_SBC_1	0.1111
p.S53F	TCGA-C5-A8XJ	CESC	TCGA	VTSTS	DEG_SPOP_SBC_1	0.7982
p.S53F	DO49902	CESC	ICGC	VTSTS	DEG_SPOP_SBC_1	0.7982
p.C58R	TCGA-CD-A48A	STAD	TCGA	VTSTS	DEG_SPOP_SBC_1	0.25
p.C58R	DO47781	STAD	ICGC	VTSTS	DEG_SPOP_SBC_1	0.25
p.S59C	TCGA-CR-6472	HNSC	TCGA	VTSTS	DEG_SPOP_SBC_1	0.2222
p.S59C	DO15870	HNSC	ICGC	VTSTS	DEG_SPOP_SBC_1	0.2222
p.G47E	TCGA-EB-A3Y7	SKCM	TCGA	VTSTS	DEG_SPOP_SBC_1	0.2222
p.G47E	DO37499	SKCM	ICGC	VTSTS	DEG_SPOP_SBC_1	0.2222
p.S55F	TCGA-IH-A3EA	SKCM	TCGA	VTSTS	DEG_SPOP_SBC_1	0.7982
p.S55F	DO222595	MELA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.7982
p.S55F	DO37667	SKCM	ICGC	VTSTS	DEG_SPOP_SBC_1	0.7982
p.A41S	DO228976	LICA	ICGC	VTSTS	DEG_SPOP_SBC_1	0.0556
p.V51I	DO51142	PRAD	ICGC	VTSTS	DEG_SPOP_SBC_1	0.7076
p.S59Y	SIDM00789	Colorectal Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.2222
p.S59Y	ACH-000997	Colon/Colorectal Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	0.2222
p.S59Y	HCT-15	large_intestine	COSMIC	VTSTS	DEG_SPOP_SBC_1	0.2222
p.R65H	SIDM00878	Breast Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.0556
p.R65H	SIDM00534	Colorectal Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.0556
p.R65H	ACH-000930	Breast Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	0.0556
p.R65H	ACH-000986	Colon/Colorectal Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	0.0556
p.R65H	HCC1569	breast	COSMIC	VTSTS	DEG_SPOP_SBC_1	0.0556
p.R65H	HT-115	large_intestine	COSMIC	VTSTS	DEG_SPOP_SBC_1	0.0556
p.G47R	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	0.2222
p.G47R	ACH-000318	Esophageal Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	0.2222
p.G47R	TE-10	oesophagus	COSMIC	VTSTS	DEG_SPOP_SBC_1	0.2222
p.R45Q	CP66-MEL	skin	COSMIC	VTSTS	DEG_SPOP_SBC_1	0.1667
p.S61L	COLO-783	skin	COSMIC	VTSTS	DEG_SPOP_SBC_1	0.1667
p.R51H	NY	bone	COSMIC	VTSTS	DEG_SPOP_SBC_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1A519	Protein FAM170A	DEG_SPOP_SBC_1	51:55	VTSTS	SPOP	0.8827	More...
O75475	PC4 and SFRS1-interacting protein	DEG_SPOP_SBC_1	269:273	VTSTS	SPOP	0.9904	More...
P35638	DNA damage-inducible transcript 3 protein	DEG_SPOP_SBC_1	73:77	VTSTS	SPOP	0.8287	More...
Q01546	Keratin, type II cytoskeletal 2 oral	DEG_SPOP_SBC_1	512:516	VTSTS	SPOP	0.6377	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	804:808	VTSTS	SPOP	0.8927	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1557:1561	VTSTS	SPOP	0.8949	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	787:791	VTSTS	SPOP	0.9967	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1761:1765	VTSTS	SPOP	0.5627	More...
Q7Z7A1	Centriolin	DEG_SPOP_SBC_1	2288:2292	VTSTS	SPOP	0.8742	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1248:1252	VTSTS	SPOP	0.959	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1139:1143	VTSTS	SPOP	0.9584	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1376:1380	VTSTS	SPOP	0.995	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1801:1805	VTSTS	SPOP	0.9919	More...
Q96T58	Msx2-interacting protein	DEG_SPOP_SBC_1	2549:2553	VTSTS	SPOP	0.9158	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	1006:1010	VTSTS	SPOP	0.8996	More...
Q8NET4	Retrotransposon Gag-like protein 9	DEG_SPOP_SBC_1	870:874	VTSTS	SPOP	0.9347	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTSTS

Degron related mutations and impact score

Drug responses associated with FAM170A mutations

All proteins holding degron of VTSTS