DegronMD - Q8NET4(RTL9)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M105I	SIDM02045	Colorectal Carcinoma	GDSC	DSGALS	DEG_SCF_TRCP1_1	96:101	Mutation rewiring degron network	0.2222
p.M105I	SIDM02045	Colorectal Carcinoma	GDSC	DSGALS	DEG_SCF_TRCP1_1	109:114	Mutation rewiring degron network	0.2222
p.A436T	SIDM01310	Esophageal Carcinoma	GDSC	AMTTS	DEG_SPOP_SBC_1	436:440	Mutation altering degron motif	0.7139
p.A436T	SIDM01311	Esophageal Carcinoma	GDSC	AMTTS	DEG_SPOP_SBC_1	436:440	Mutation altering degron motif	0.7139
p.T590M	SIDM00773	Non-Cancerous	GDSC	MSTPLMT	DEG_SCF_FBW7_1	575:581	Mutation rewiring degron network	0.0833
p.T590M	SIDM00431	T-Lymphoblastic Leukemia	GDSC	MSTPLMT	DEG_SCF_FBW7_1	575:581	Mutation rewiring degron network	0.0833
p.A1026T	SIDM00007	Other Solid Cancers	GDSC	ARSTS	DEG_SPOP_SBC_1	1026:1030	Mutation altering degron motif	0.7139
p.A1026T	MCC13	skin	COSMIC	ARSTS	DEG_SPOP_SBC_1	1026:1030	Mutation altering degron motif	0.7139
p.A107S	SIDM00741	Small Cell Lung Carcinoma	GDSC	DSGALS	DEG_SCF_TRCP1_1	96:101	Mutation rewiring degron network	0.1667
p.A107S	SIDM00741	Small Cell Lung Carcinoma	GDSC	DSGALS	DEG_SCF_TRCP1_1	109:114	Mutation rewiring degron network	0.2778
p.A107S	NCI-H1694	lung	COSMIC	DSGALS	DEG_SCF_TRCP1_1	96:101	Mutation rewiring degron network	0.1667
p.A107S	NCI-H1694	lung	COSMIC	DSGALS	DEG_SCF_TRCP1_1	109:114	Mutation rewiring degron network	0.2778
p.G293R	SIDM00522	Small Cell Lung Carcinoma	GDSC	IPTPLMS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.3056
p.G293R	SIDM00522	Small Cell Lung Carcinoma	GDSC	DSGIMSS	DEG_SCF_TRCP1_1	303:309	Mutation rewiring degron network	0.0556
p.G293R	SIDM00140	Melanoma	GDSC	IPTPLMS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.3056
p.G293R	SIDM00140	Melanoma	GDSC	DSGIMSS	DEG_SCF_TRCP1_1	303:309	Mutation rewiring degron network	0.0556
p.G293R	DMS-273	lung	COSMIC	IPTPLMS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.3056
p.G293R	DMS-273	lung	COSMIC	DSGIMSS	DEG_SCF_TRCP1_1	303:309	Mutation rewiring degron network	0.0556
p.G293R	COLO-792	skin	COSMIC	IPTPLMS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.3056
p.G293R	COLO-792	skin	COSMIC	DSGIMSS	DEG_SCF_TRCP1_1	303:309	Mutation rewiring degron network	0.0556
p.G293E	SIDM00221	Melanoma	GDSC	IPTPLMS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.3056
p.G293E	SIDM00221	Melanoma	GDSC	DSGIMSS	DEG_SCF_TRCP1_1	303:309	Mutation rewiring degron network	0.0556
p.G677R	SIDM01220	Glioma	GDSC	AMSTS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.3056
p.G677R	LNZTA3WT4	central nervous system	COSMIC	AMSTS	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.3056
p.M619T	SIDM00574	Glioblastoma	GDSC	PLMTPKAS	DEG_SCF_FBW7_1	617:624	Mutation altering degron motif	0.6312
p.M619T	no-10	central nervous system	COSMIC	PLMTPKAS	DEG_SCF_FBW7_1	617:624	Mutation altering degron motif	0.6312
p.P578T	SIDM01133	Other Solid Cancers	GDSC	MSTPLMT	DEG_SCF_FBW7_1	575:581	Mutation altering degron motif	0.7031
p.P578T	NCI-H835	lung	COSMIC	MSTPLMT	DEG_SCF_FBW7_1	575:581	Mutation altering degron motif	0.7031
p.S131P	SIDM00217	Colorectal Carcinoma	GDSC	DSGTLS	DEG_SCF_TRCP1_1	122:127	Mutation rewiring degron network	0.2222
p.S131P	SNU-1040	large intestine	COSMIC	DSGTLS	DEG_SCF_TRCP1_1	122:127	Mutation rewiring degron network	0.2222
p.V403G	SIDM00679	Cervical Carcinoma	GDSC	DSGAMST	DEG_SCF_TRCP1_1	407:413	Mutation rewiring degron network	0.2222
p.V403G	HT-3	cervix	COSMIC	DSGAMST	DEG_SCF_TRCP1_1	407:413	Mutation rewiring degron network	0.2222
p.P419T	SIDM01612	Endometrial Carcinoma	GDSC	DSGAMST	DEG_SCF_TRCP1_1	407:413	Mutation rewiring degron network	0.1667
p.S304F	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	DSGIMSS	DEG_SCF_TRCP1_1	303:309	Mutation altering degron motif	0.7982
p.S868F	SIDM01448	Head and Neck Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.2778
p.S1108A	SIDM01619	Endometrial Carcinoma	GDSC	DSGEAST	DEG_SCF_TRCP1_1	1101:1107	Mutation rewiring degron network	0.3056
p.S287N	HCT-15	large intestine	COSMIC	IPTPLMS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.1389
p.D867A	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	VTSTS	DEG_SPOP_SBC_1	870:874	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RTL9

UniProt ID: Q8NET4

Entrez ID: 57529

Protein name: Retrotransposon Gag-like protein 9 (Retrotransposon gag domain-containing protein 1) (Tumor antigen BJ-HCC-23)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RTL9 in