DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
AMTTS
Uniprot ID:
Q8NET4
Source protein:
Retrotransposon Gag-like protein 9
Source gene:
RTL9
Class:
DEG_SPOP_SBC_1
Location:
436:440
E3 ligase:
SPOP
DEGRON score:
0.8872
ASA_SCORE:
92.16
COIL:
0.9218
CONS_SCORE:
0.4604
DSS_SCORE:
0.4903
HELIX:
0.0388
FCONS_SCORE:
1.0453
RIG_SCORE:
0.7131
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A436T
SIDM01310
Esophageal Carcinoma
GDSC
AMTTS
DEG_SPOP_SBC_1
0.7139
p.A436T
SIDM01311
Esophageal Carcinoma
GDSC
AMTTS
DEG_SPOP_SBC_1
0.7139
Drug responses associated with RTL9 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AMTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NET4
Retrotransposon Gag-like protein 9
DEG_SPOP_SBC_1
436:440
AMTTS
SPOP
0.8872
More...