DegronMD

Uniprot ID: Q8NET4

Source protein: Retrotransposon Gag-like protein 9

Source gene: RTL9

Class: DEG_SCF_FBW7_1

Location: 575:581

E3 ligase: FBXW7

DEGRON score: 0.7757

ASA_SCORE: 101.7714

COIL: 0.9071

CONS_SCORE: 0.4984

DSS_SCORE: 0.547

HELIX: 0.044

FCONS_SCORE: 1.0632

RIG_SCORE: 0.7216

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T590M	SIDM00773	Non-Cancerous	GDSC	MSTPLMT	DEG_SCF_FBW7_1	0.0833
p.T590M	SIDM00431	T-Lymphoblastic Leukemia	GDSC	MSTPLMT	DEG_SCF_FBW7_1	0.0833
p.P578T	SIDM01133	Other Solid Cancers	GDSC	MSTPLMT	DEG_SCF_FBW7_1	0.7031
p.P578T	NCI-H835	lung	COSMIC	MSTPLMT	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NET4	Retrotransposon Gag-like protein 9	DEG_SCF_FBW7_1	575:581	MSTPLMT	FBXW7	0.7757	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons