DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
AMSTS
Uniprot ID:
Q8NET4
Source protein:
Retrotransposon Gag-like protein 9
Source gene:
RTL9
Class:
DEG_SPOP_SBC_1
Location:
678:682
E3 ligase:
SPOP
DEGRON score:
0.9169
ASA_SCORE:
90.38
COIL:
0.8868
CONS_SCORE:
0.3623
DSS_SCORE:
0.5463
HELIX:
0.0668
FCONS_SCORE:
0.8316
RIG_SCORE:
0.6521
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G677R
SIDM01220
Glioma
GDSC
AMSTS
DEG_SPOP_SBC_1
0.3056
p.G677R
LNZTA3WT4
central_nervous_system
COSMIC
AMSTS
DEG_SPOP_SBC_1
0.3056
Drug responses associated with RTL9 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AMSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IZF6
Adhesion G-protein coupled receptor G4
DEG_SPOP_SBC_1
543:547
AMSTS
SPOP
0.9609
More...
Q8NET4
Retrotransposon Gag-like protein 9
DEG_SPOP_SBC_1
678:682
AMSTS
SPOP
0.9169
More...