DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
AMSTS
Uniprot ID:
Q8NET4
Source protein:
Retrotransposon Gag-like protein 9
Source gene:
RTL9
Class:
DEG_SPOP_SBC_1
Location:
678:682
E3 ligase:
SPOP
DEGRON score:
0.9169
ASA_SCORE:
90.38
COIL:
0.8868
CONS_SCORE:
0.3623
DSS_SCORE:
0.5463
HELIX:
0.0668
FCONS_SCORE:
0.8316
RIG_SCORE:
0.6521
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G677R
SIDM01220
Glioma
GDSC
AMSTS
DEG_SPOP_SBC_1
0.3056
p.G677R
LNZTA3WT4
central_nervous_system
COSMIC
AMSTS
DEG_SPOP_SBC_1
0.3056
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Drug responses associated with RTL9 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of AMSTS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IZF6
Adhesion G-protein coupled receptor G4
DEG_SPOP_SBC_1
543:547
AMSTS
SPOP
0.9609
More...
Q8NET4
Retrotransposon Gag-like protein 9
DEG_SPOP_SBC_1
678:682
AMSTS
SPOP
0.9169
More...
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