DegronMD - Q8IZF6(ADGRG4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I1885T	SIDM00491	Thyroid Gland Carcinoma	GDSC	PISTT	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.0833
p.I1885T	ASH-3	thyroid	COSMIC	PISTT	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.0833
p.S1778F	SIDM01199	Hepatocellular Carcinoma	GDSC	VKTTT	DEG_SPOP_SBC_1	1784:1788	Mutation rewiring degron network	0.1667
p.S1778F	SNU-423	liver	COSMIC	VKTTT	DEG_SPOP_SBC_1	1784:1788	Mutation rewiring degron network	0.1667
p.R921K	SIDM01175	Other Sarcomas	GDSC	VKTTPRSS	DEG_SCF_FBW7_1	916:923	Mutation altering degron motif	0.6126
p.R921K	SW684	soft tissue	COSMIC	VKTTPRSS	DEG_SCF_FBW7_1	916:923	Mutation altering degron motif	0.6126
p.A646T	SIDM00007	Other Solid Cancers	GDSC	PTSTT	DEG_SPOP_SBC_1	638:642	Mutation rewiring degron network	0.2222
p.A646T	MCC13	skin	COSMIC	PTSTT	DEG_SPOP_SBC_1	638:642	Mutation rewiring degron network	0.2222
p.S1904Y	SIDM00343	Glioblastoma	GDSC	PISTT	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.1667
p.S1904Y	LN-405	central nervous system	COSMIC	PISTT	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.1667
p.L1343S	SIDM00206	Glioblastoma	GDSC	ITPTLT	DEG_SCF_FBW7_1	1339:1344	Mutation altering degron motif	0.6556
p.L1343S	D-566MG	central nervous system	COSMIC	ITPTLT	DEG_SCF_FBW7_1	1339:1344	Mutation altering degron motif	0.6556
p.S386Y	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	VVSTT	DEG_SPOP_SBC_1	384:388	Mutation altering degron motif	0.712
p.S386Y	NCI-H2126	lung	COSMIC	VVSTT	DEG_SPOP_SBC_1	384:388	Mutation altering degron motif	0.712
p.R581H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LTPEIT	DEG_SCF_FBW7_1	584:589	Mutation rewiring degron network	0.25
p.R581H	NALM-6	haematopoietic and lymphoid tissue	COSMIC	LTPEIT	DEG_SCF_FBW7_1	584:589	Mutation rewiring degron network	0.25
p.G1890R	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PISTT	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.2222
p.G1890R	NCI-H650	lung	COSMIC	PISTT	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.2222
p.T1348R	SIDM00837	Colorectal Carcinoma	GDSC	ITPTLT	DEG_SCF_FBW7_1	1339:1344	Mutation rewiring degron network	0.2222
p.T1348R	SW48	large intestine	COSMIC	ITPTLT	DEG_SCF_FBW7_1	1339:1344	Mutation rewiring degron network	0.2222
p.T1165M	SIDM00239	Kidney Carcinoma	GDSC	VISTT	DEG_SPOP_SBC_1	1161:1165	Mutation altering degron motif	0.7423
p.T1165M	OS-RC-2	kidney	COSMIC	VISTT	DEG_SPOP_SBC_1	1161:1165	Mutation altering degron motif	0.7423
p.R1097M	SIDM00373	Endometrial Carcinoma	GDSC	TSMAVPSL	DEG_COP1_1	1099:1106	Mutation rewiring degron network	0.2778
p.R1097M	SIDM00373	Endometrial Carcinoma	GDSC	LTETPFHS	DEG_SCF_FBW7_1	1106:1113	Mutation rewiring degron network	0.0833
p.R1097M	SNG-M	endometrium	COSMIC	TSMAVPSL	DEG_COP1_1	1099:1106	Mutation rewiring degron network	0.2778
p.R1097M	SNG-M	endometrium	COSMIC	LTETPFHS	DEG_SCF_FBW7_1	1106:1113	Mutation rewiring degron network	0.0833
p.P1429T	SIDM00549	B-Lymphoblastic Leukemia	GDSC	VDTTT	DEG_SPOP_SBC_1	1416:1420	Mutation rewiring degron network	0.0833
p.P1429T	LC4-1	haematopoietic and lymphoid tissue	COSMIC	VDTTT	DEG_SPOP_SBC_1	1416:1420	Mutation rewiring degron network	0.0833
p.T1986I	SIDM01042	Breast Carcinoma	GDSC	VTPGTT	DEG_SCF_FBW7_1	1982:1987	Mutation altering degron motif	0.5966
p.T1986I	EVSA-T	breast	COSMIC	VTPGTT	DEG_SCF_FBW7_1	1982:1987	Mutation altering degron motif	0.5966
p.P1149H	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	1155:1159	Mutation rewiring degron network	0.1667
p.P1149H	NCI-H1793	lung	COSMIC	PASST	DEG_SPOP_SBC_1	1155:1159	Mutation rewiring degron network	0.1667
p.T641R	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTSTT	DEG_SPOP_SBC_1	638:642	Mutation altering degron motif	0.7876
p.T641R	Farage	haematopoietic and lymphoid tissue	COSMIC	PTSTT	DEG_SPOP_SBC_1	638:642	Mutation altering degron motif	0.7876
p.M1885V	CTB-1	haematopoietic and lymphoid tissue	COSMIC	PISTT	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.0833
p.Y1895H	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PISTT	DEG_SPOP_SBC_1	1894:1898	Mutation altering degron motif	0.7229
p.S2039F	451Lu	skin	COSMIC	VMTSS	DEG_SPOP_SBC_1	2029:2033	Mutation substituting flanking lysine	0.2778
p.G1412R	NCI-H1155	lung	COSMIC	VDTTT	DEG_SPOP_SBC_1	1416:1420	Mutation rewiring degron network	0.2222
p.R376H	NALM-6	haematopoietic and lymphoid tissue	COSMIC	VVSTT	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1111
p.P792T	huH-1	liver	COSMIC	TPRETVVPSV	DEG_COP1_1	777:786	Mutation rewiring degron network	0.1667
p.L790S	SK-GT-2	stomach	COSMIC	TPRETVVPSV	DEG_COP1_1	777:786	Mutation rewiring degron network	0.2222
p.L790S	SK-GT-2	stomach	COSMIC	LPLTPRET	DEG_SCF_FBW7_1	774:781	Mutation rewiring degron network	0.0833
p.P1118L	ES-2	ovary	COSMIC	LTETPFHS	DEG_SCF_FBW7_1	1106:1113	Mutation rewiring degron network	0.1944
p.E548K	SNU-C5	large intestine	COSMIC	AMSTS	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.3056
p.F1988Y	DB	haematopoietic and lymphoid tissue	COSMIC	VTPGTT	DEG_SCF_FBW7_1	1982:1987	Mutation rewiring degron network	0.3056
p.T1094K	NCI-H446	lung	COSMIC	TSMAVPSL	DEG_COP1_1	1099:1106	Mutation rewiring degron network	0.1944
p.S2030L	SAS	upper aerodigestive tract	COSMIC	VMTSS	DEG_SPOP_SBC_1	2029:2033	Mutation altering degron motif	0.7667
p.T1781I	EVSA-T	breast	COSMIC	VKTTT	DEG_SPOP_SBC_1	1784:1788	Mutation rewiring degron network	0.25
p.H1899D	NCI-H209	lung	COSMIC	PISTT	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.3056
p.R629I	HCC2998	large intestine	COSMIC	PTSTT	DEG_SPOP_SBC_1	638:642	Mutation rewiring degron network	0.0833
p.F594C	HCC2998	large intestine	COSMIC	LTPEIT	DEG_SCF_FBW7_1	584:589	Mutation rewiring degron network	0.1944
p.P1173S	MCC13	skin	COSMIC	VISTT	DEG_SPOP_SBC_1	1161:1165	Mutation rewiring degron network	0.1111
p.L1973I	NCI-H835	lung	COSMIC	VTPGTT	DEG_SCF_FBW7_1	1982:1987	Mutation rewiring degron network	0.0833
p.L1973I	NCI-H835	lung	COSMIC	AITST	DEG_SPOP_SBC_1	1963:1967	Mutation rewiring degron network	0.1667
p.G1095R	CP67-MEL	skin	COSMIC	TSMAVPSL	DEG_COP1_1	1099:1106	Mutation rewiring degron network	0.2222
p.H1339P	MCC13	skin	COSMIC	ITPTLT	DEG_SCF_FBW7_1	1339:1344	Mutation altering degron motif	0.7694
p.D929Y	COLO-679	skin	COSMIC	VKTTPRSS	DEG_SCF_FBW7_1	916:923	Mutation rewiring degron network	0.1667
p.S277F	ML-1	thyroid	COSMIC	AHSST	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.0833
p.R1905K	M14	skin	COSMIC	PISTT	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.1389
p.L1123F	LK-2	lung	COSMIC	LTETPFHS	DEG_SCF_FBW7_1	1106:1113	Mutation substituting flanking lysine	0.1667
p.T781R	BC-3	haematopoietic and lymphoid tissue	COSMIC	TPRETVVPSV	DEG_COP1_1	777:786	Mutation altering degron motif	0.6765
p.T781R	BC-3	haematopoietic and lymphoid tissue	COSMIC	LPLTPRET	DEG_SCF_FBW7_1	774:781	Mutation altering degron motif	0.7876

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADGRG4

UniProt ID: Q8IZF6

Entrez ID: 139378

Protein name: Adhesion G-protein coupled receptor G4 (G-protein coupled receptor 112)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADGRG4 in