DegronMD

Uniprot ID: Q8IZF6

Source protein: Adhesion G-protein coupled receptor G4

Source gene: ADGRG4

Class: DEG_SCF_FBW7_1

Location: 1106:1113

E3 ligase: FBXW7

DEGRON score: 0.8683

ASA_SCORE: 100.225

COIL: 0.892

CONS_SCORE: 0.7712

DSS_SCORE: 0.3791

HELIX: 0.0284

FCONS_SCORE: 1.0144

RIG_SCORE: 0.7662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1097M	SIDM00373	Endometrial Carcinoma	GDSC	LTETPFHS	DEG_SCF_FBW7_1	0.0833
p.R1097M	SNG-M	endometrium	COSMIC	LTETPFHS	DEG_SCF_FBW7_1	0.0833
p.P1118L	ES-2	ovary	COSMIC	LTETPFHS	DEG_SCF_FBW7_1	0.1944
p.L1123F	LK-2	lung	COSMIC	LTETPFHS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SCF_FBW7_1	1106:1113	LTETPFHS	FBXW7	0.8683	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons