DegronMD

Uniprot ID: Q8IZF6

Source protein: Adhesion G-protein coupled receptor G4

Source gene: ADGRG4

Class: DEG_SCF_FBW7_1

Location: 916:923

E3 ligase: FBXW7

DEGRON score: 0.5957

ASA_SCORE: 96.2125

COIL: 0.8225

CONS_SCORE: 0.7562

DSS_SCORE: 0.3076

HELIX: 0.0214

FCONS_SCORE: 1.001

RIG_SCORE: 0.7924

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R921K	SIDM01175	Other Sarcomas	GDSC	VKTTPRSS	DEG_SCF_FBW7_1	0.6126
p.R921K	SW684	soft_tissue	COSMIC	VKTTPRSS	DEG_SCF_FBW7_1	0.6126
p.D929Y	COLO-679	skin	COSMIC	VKTTPRSS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SCF_FBW7_1	916:923	VKTTPRSS	FBXW7	0.5957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons