DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
VKTTT
Uniprot ID:
Q8IZF6
Source protein:
Adhesion G-protein coupled receptor G4
Source gene:
ADGRG4
Class:
DEG_SPOP_SBC_1
Location:
1784:1788
E3 ligase:
SPOP
DEGRON score:
0.7189
ASA_SCORE:
90.78
COIL:
0.728
CONS_SCORE:
0.7648
DSS_SCORE:
0.4716
HELIX:
0.0348
FCONS_SCORE:
0.9953
RIG_SCORE:
0.7667
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S1778F
SIDM01199
Hepatocellular Carcinoma
GDSC
VKTTT
DEG_SPOP_SBC_1
0.1667
p.S1778F
SNU-423
liver
COSMIC
VKTTT
DEG_SPOP_SBC_1
0.1667
p.T1781I
EVSA-T
breast
COSMIC
VKTTT
DEG_SPOP_SBC_1
0.25
Drug responses associated with ADGRG4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VKTTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A4UGR9
Xin actin-binding repeat-containing protein 2
DEG_SPOP_SBC_1
1347:1351
VKTTT
SPOP
0.8769
More...
Q8IZF6
Adhesion G-protein coupled receptor G4
DEG_SPOP_SBC_1
1784:1788
VKTTT
SPOP
0.7189
More...