DegronMD

Uniprot ID: A4UGR9

Source protein: Xin actin-binding repeat-containing protein 2

Source gene: XIRP2

Class: DEG_SPOP_SBC_1

Location: 1347:1351

E3 ligase: SPOP

DEGRON score: 0.8769

ASA_SCORE: 76.9

COIL: 0.5508

CONS_SCORE: 0.9307

DSS_SCORE: 0.4521

HELIX: 0.0414

FCONS_SCORE: 1.1849

RIG_SCORE: 0.8133

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1346Y	TCGA-05-4427	LUAD	TCGA	VKTTT	DEG_SPOP_SBC_1	0.3056
p.D1346Y	DO23666	LUAD	ICGC	VKTTT	DEG_SPOP_SBC_1	0.3056
p.S1361Y	TCGA-33-AASB	LUSC	TCGA	VKTTT	DEG_SPOP_SBC_1	0.0556
p.S1361Y	TCGA-AN-A046	BRCA	TCGA	VKTTT	DEG_SPOP_SBC_1	0.0556
p.S1361Y	TCGA-BK-A6W3	UCEC	TCGA	VKTTT	DEG_SPOP_SBC_1	0.0556
p.S1361Y	DO1285	BRCA	ICGC	VKTTT	DEG_SPOP_SBC_1	0.0556
p.S1361Y	DO219125	LUSC	ICGC	VKTTT	DEG_SPOP_SBC_1	0.0556
p.S1361Y	DO50076	UCEC	ICGC	VKTTT	DEG_SPOP_SBC_1	0.0556
p.S1361Y	SIDM00193	Colorectal Carcinoma	GDSC	VKTTT	DEG_SPOP_SBC_1	0.0556
p.S1361Y	ACH-000991	Colon/Colorectal Cancer	CCLE	VKTTT	DEG_SPOP_SBC_1	0.0556
p.S1361Y	SNU-81	large_intestine	COSMIC	VKTTT	DEG_SPOP_SBC_1	0.0556
p.V1342L	TCGA-78-7155	LUAD	TCGA	VKTTT	DEG_SPOP_SBC_1	0.1944
p.V1342L	DO23590	LUAD	ICGC	VKTTT	DEG_SPOP_SBC_1	0.1944
p.R1351M	TCGA-86-6562	LUAD	TCGA	VKTTT	DEG_SPOP_SBC_1	0.8632
p.R1351M	DO24013	LUAD	ICGC	VKTTT	DEG_SPOP_SBC_1	0.8632
p.V1342I	TCGA-B5-A3FC	UCEC	TCGA	VKTTT	DEG_SPOP_SBC_1	0.1944
p.V1342I	DO41871	UCEC	ICGC	VKTTT	DEG_SPOP_SBC_1	0.1944
p.H1344N	TCGA-BR-8680	STAD	TCGA	VKTTT	DEG_SPOP_SBC_1	0.25
p.H1344N	DO47769	STAD	ICGC	VKTTT	DEG_SPOP_SBC_1	0.25
p.D1360Y	TCGA-BS-A0UF	UCEC	TCGA	VKTTT	DEG_SPOP_SBC_1	0.0833
p.D1360Y	DO41488	UCEC	ICGC	VKTTT	DEG_SPOP_SBC_1	0.0833
p.H1344Y	TCGA-EE-A2MT	SKCM	TCGA	VKTTT	DEG_SPOP_SBC_1	0.25
p.H1344Y	DO220895	MELA	ICGC	VKTTT	DEG_SPOP_SBC_1	0.25
p.H1344Y	DO38051	SKCM	ICGC	VKTTT	DEG_SPOP_SBC_1	0.25
p.L1353P	DO50406	ESAD	ICGC	VKTTT	DEG_SPOP_SBC_1	0.2778
p.L1353R	DO234153	ESAD	ICGC	VKTTT	DEG_SPOP_SBC_1	0.2778
p.G1349V	DO234239	ESAD	ICGC	VKTTT	DEG_SPOP_SBC_1	0.7532
p.G1349R	DO45141	LIRI	ICGC	VKTTT	DEG_SPOP_SBC_1	0.7568
p.T1350K	DO224563	LUSC	ICGC	VKTTT	DEG_SPOP_SBC_1	0.7306
p.R1348Q	SIDM00674	Non-Cancerous	GDSC	VKTTT	DEG_SPOP_SBC_1	0.7329
p.R1348Q	SIDM00675	Breast Carcinoma	GDSC	VKTTT	DEG_SPOP_SBC_1	0.7329
p.F1354L	SIDM01220	Glioma	GDSC	VKTTT	DEG_SPOP_SBC_1	0.25
p.F1354L	ACH-002269	Brain Cancer	CCLE	VKTTT	DEG_SPOP_SBC_1	0.25
p.F1354L	LNZTA3WT4	central_nervous_system	COSMIC	VKTTT	DEG_SPOP_SBC_1	0.25
p.E1340A	SIDM01490	Small Cell Lung Carcinoma	GDSC	VKTTT	DEG_SPOP_SBC_1	0.1389
p.E1340A	ACH-000382	Lung Cancer	CCLE	VKTTT	DEG_SPOP_SBC_1	0.1389
p.V1347F	SK-MES-1	lung	COSMIC	VKTTT	DEG_SPOP_SBC_1	0.7068
p.D1346N	DMS-53	lung	COSMIC	VKTTT	DEG_SPOP_SBC_1	0.3056
p.D1346N	MDA-MB-361	breast	COSMIC	VKTTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	1347:1351	VKTTT	SPOP	0.8769	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1784:1788	VKTTT	SPOP	0.7189	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VKTTT

Degron related mutations and impact score

Drug responses associated with XIRP2 mutations

All proteins holding degron of VKTTT