DegronMD - A4UGR9(XIRP2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K2885N	TCGA-05-4398	LUAD	TCGA	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.0833
p.K2885N	DO25847	LUAD	ICGC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.0833
p.D1346Y	TCGA-05-4427	LUAD	TCGA	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.3056
p.D1346Y	DO23666	LUAD	ICGC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.3056
p.M242I	TCGA-14-0866	GBM	TCGA	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1389
p.M242I	DO11878	GBM	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1389
p.M242I	DO229177	LMS	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1389
p.E2900K	TCGA-19-5956	GBM	TCGA	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.2778
p.E2900K	TCGA-AZ-6601	COAD	TCGA	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.2778
p.E2900K	DO8119	COAD	ICGC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.2778
p.E2900K	DO13863	GBM	ICGC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.2778
p.E2900K	SIDM01611	Endometrial Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.2778
p.G1270E	TCGA-21-1079	LUSC	TCGA	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.2222
p.G1270E	DO26846	LUSC	ICGC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.2222
p.N2792S	TCGA-2Y-A9GZ	LIHC	TCGA	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.0833
p.N2792S	DO219517	LIHC	ICGC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.0833
p.H2770R	TCGA-33-AAS8	LUSC	TCGA	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.1944
p.H2770R	DO219123	LUSC	ICGC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.1944
p.S1361Y	TCGA-33-AASB	LUSC	TCGA	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.0556
p.S1361Y	TCGA-AN-A046	BRCA	TCGA	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.0556
p.S1361Y	TCGA-BK-A6W3	UCEC	TCGA	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.0556
p.S1361Y	DO1285	BRCA	ICGC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.0556
p.S1361Y	DO219125	LUSC	ICGC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.0556
p.S1361Y	DO50076	UCEC	ICGC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.0556
p.S1361Y	SIDM00193	Colorectal Carcinoma	GDSC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.0556
p.S1361Y	ACH-000991	Colon/Colorectal Cancer	CCLE	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.0556
p.S1361Y	SNU-81	large intestine	COSMIC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.0556
p.D1271N	TCGA-3N-A9WC	SKCM	TCGA	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation substituting flanking lysine	0.3611
p.D1271N	DO51234	SKCM	ICGC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation substituting flanking lysine	0.3611
p.I2789T	TCGA-43-3394	LUSC	TCGA	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.1667
p.I2789T	DO26596	LUSC	ICGC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.1667
p.E2906D	TCGA-50-5939	LUAD	TCGA	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.1111
p.E2906D	TCGA-EO-A3AV	UCEC	TCGA	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.1111
p.E2906D	DO25183	LUAD	ICGC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.1111
p.E2906D	DO52412	UCEC	ICGC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.1111
p.K2902R	TCGA-55-8092	LUAD	TCGA	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.2222
p.K2902R	TCGA-BL-A13I	BLCA	TCGA	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.2222
p.K2902R	DO452	BLCA	ICGC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.2222
p.K2902R	DO26220	LUAD	ICGC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.2222
p.E1280V	TCGA-60-2723	LUSC	TCGA	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.2778
p.E1280V	DO27152	LUSC	ICGC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.2778
p.P2294L	TCGA-63-A5MM	LUSC	TCGA	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation altering degron motif	0.7582
p.P2294L	DO219153	LUSC	ICGC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation altering degron motif	0.7582
p.D165Y	TCGA-64-5781	LUAD	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.1111
p.D165Y	DO23740	LUAD	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.1111
p.S2285R	TCGA-68-7755	LUSC	TCGA	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.1111
p.S2285R	DO26512	LUSC	ICGC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.1111
p.V1342L	TCGA-78-7155	LUAD	TCGA	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.1944
p.V1342L	DO23590	LUAD	ICGC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.1944
p.S239Y	TCGA-85-6561	LUSC	TCGA	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.2222
p.S239Y	TCGA-GE-A2C6	THCA	TCGA	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.2222
p.S239Y	DO26518	LUSC	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.2222
p.S239Y	DO40334	THCA	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.2222
p.R1351M	TCGA-86-6562	LUAD	TCGA	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation altering degron motif	0.8632
p.R1351M	DO24013	LUAD	ICGC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation altering degron motif	0.8632
p.E263K	TCGA-86-8278	LUAD	TCGA	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.3056
p.E263K	DO26308	LUAD	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.3056
p.E187D	TCGA-91-6848	LUAD	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.1389
p.E187D	DO23846	LUAD	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.1389
p.A256V	TCGA-99-8025	LUAD	TCGA	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.2778
p.A256V	DO24255	LUAD	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.2778
p.S2285N	TCGA-A5-A0G2	UCEC	TCGA	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.1111
p.S2285N	DO41235	UCEC	ICGC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.1111
p.M248V	TCGA-A8-A09Q	BRCA	TCGA	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.M248V	DO1579	BRCA	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.Q2793H	TCGA-AJ-A3EK	UCEC	TCGA	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.0556
p.Q2793H	DO41584	UCEC	ICGC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.0556
p.S1283Y	TCGA-AP-A059	UCEC	TCGA	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation blocking phosphorylation signal	0.6389
p.S1283Y	TCGA-CA-6718	COAD	TCGA	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation blocking phosphorylation signal	0.6389
p.S1283Y	TCGA-EO-A3B0	UCEC	TCGA	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation blocking phosphorylation signal	0.6389
p.S1283Y	DO7801	COAD	ICGC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation blocking phosphorylation signal	0.6389
p.S1283Y	DO219773	UCEC	ICGC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation blocking phosphorylation signal	0.6389
p.S1283Y	DO41361	UCEC	ICGC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation blocking phosphorylation signal	0.6389
p.A224V	TCGA-AP-A1DV	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1389
p.A224V	DO32908	PACA	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1389
p.A224V	DO43186	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1389
p.H182D	TCGA-AR-A1AJ	BRCA	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.2778
p.H182D	DO4062	BRCA	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.2778
p.R1273I	TCGA-AR-A250	BRCA	TCGA	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.3056
p.R1273I	DO1802	BRCA	ICGC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.3056
p.E265K	TCGA-AX-A2HC	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.25
p.E265K	TCGA-ER-A2NC	SKCM	TCGA	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.25
p.E265K	DO47318	SKCM	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.25
p.E265K	DO41572	UCEC	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.25
p.R270H	TCGA-AX-A2HC	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.R270H	DO41572	UCEC	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.R270H	SIDM00007	Other Solid Cancers	GDSC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.R270H	SIDM00209	Glioblastoma	GDSC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.R270H	SIDM01490	Small Cell Lung Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.S2293Y	TCGA-AX-A2HC	UCEC	TCGA	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation altering degron motif	0.712
p.S2293Y	DO41572	UCEC	ICGC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation altering degron motif	0.712
p.P2887S	TCGA-AZ-4315	COAD	TCGA	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.1389
p.P2887S	DO8842	COAD	ICGC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.1389
p.P2887S	DO233823	GACA	ICGC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.1389
p.V2782A	TCGA-B5-A11E	UCEC	TCGA	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation altering degron motif	0.6936
p.V2782A	DO41644	UCEC	ICGC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation altering degron motif	0.6936
p.V1342I	TCGA-B5-A3FC	UCEC	TCGA	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.1944
p.V1342I	DO41871	UCEC	ICGC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.1944
p.I1267R	TCGA-BR-4361	STAD	TCGA	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.1389
p.I1267R	DO38887	STAD	ICGC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.1389
p.Q2905H	TCGA-BR-8360	STAD	TCGA	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.1389
p.Q2905H	DO47745	STAD	ICGC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.1389
p.H1344N	TCGA-BR-8680	STAD	TCGA	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.25
p.H1344N	DO47769	STAD	ICGC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.25
p.D1360Y	TCGA-BS-A0UF	UCEC	TCGA	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.0833
p.D1360Y	DO41488	UCEC	ICGC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.0833
p.F238I	TCGA-CN-4731	HNSC	TCGA	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.25
p.F238I	DO15886	HNSC	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.25
p.K166N	TCGA-CZ-4863	KIRC	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.1389
p.K166N	DO18691	KIRC	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.1389
p.G1270V	TCGA-D3-A2JH	SKCM	TCGA	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.2222
p.G1270V	DO47263	SKCM	ICGC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.2222
p.E170K	TCGA-D3-A3MV	SKCM	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.25
p.E170K	TCGA-FS-A1ZQ	SKCM	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.25
p.E170K	DO37727	SKCM	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.25
p.E170K	DO37442	SKCM	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.25
p.K1274N	TCGA-D3-A8GM	SKCM	TCGA	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation altering degron motif	0.6918
p.K1274N	DO50288	SKCM	ICGC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation altering degron motif	0.6918
p.R184H	TCGA-DM-A28C	COAD	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation substituting flanking lysine	0.3333
p.R184H	DO7778	COAD	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation substituting flanking lysine	0.3333
p.L1284I	TCGA-E9-A243	BRCA	TCGA	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.1667
p.L1284I	DO4803	BRCA	ICGC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.1667
p.D165E	TCGA-ED-A8O5	LIHC	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.1111
p.D165E	DO48558	LIHC	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.1111
p.S3279F	TCGA-EE-A29H	SKCM	TCGA	PPTY	ITCH	3280:3283	Mutation rewiring degron network	0.3056
p.S3279F	DO222875	MELA	ICGC	PPTY	ITCH	3280:3283	Mutation rewiring degron network	0.3056
p.S3279F	DO37535	SKCM	ICGC	PPTY	ITCH	3280:3283	Mutation rewiring degron network	0.3056
p.I266F	TCGA-EE-A29L	SKCM	TCGA	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.2222
p.I266F	DO222599	MELA	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.2222
p.I266F	DO37835	SKCM	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.2222
p.Q2793K	TCGA-EE-A2MQ	SKCM	TCGA	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.0556
p.Q2793K	DO37810	SKCM	ICGC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.0556
p.H1344Y	TCGA-EE-A2MT	SKCM	TCGA	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.25
p.H1344Y	DO220895	MELA	ICGC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.25
p.H1344Y	DO38051	SKCM	ICGC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.25
p.Q2888K	TCGA-EE-A3AA	SKCM	TCGA	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.1667
p.Q2888K	DO37571	SKCM	ICGC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.1667
p.S2304F	TCGA-EO-A22U	UCEC	TCGA	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.1389
p.S2304F	TCGA-WE-AAA0	SKCM	TCGA	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.1389
p.S2304F	DO51294	SKCM	ICGC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.1389
p.S2304F	DO43755	UCEC	ICGC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.1389
p.S2304F	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.1389
p.S2304F	ACH-002215	Lymphoma	CCLE	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.1389
p.S2304F	BC-3	haematopoietic and lymphoid tissue	COSMIC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.1389
p.E2895A	TCGA-ER-A198	SKCM	TCGA	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation altering degron motif	0.7701
p.E2895A	DO47563	SKCM	ICGC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation altering degron motif	0.7701
p.N2891H	TCGA-EY-A1GD	UCEC	TCGA	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.25
p.N2891H	DO42129	UCEC	ICGC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.25
p.E221K	TCGA-EY-A215	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.0556
p.E221K	DO42665	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.0556
p.Q2772P	TCGA-F5-6814	READ	TCGA	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.25
p.Q2772P	DO36556	READ	ICGC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.25
p.S231F	TCGA-FI-A2D0	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation altering degron motif	0.7982
p.S231F	DO43891	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation altering degron motif	0.7982
p.S1283F	TCGA-FR-A8YC	SKCM	TCGA	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation blocking phosphorylation signal	0.6389
p.S1283F	TCGA-FS-A4F9	SKCM	TCGA	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation blocking phosphorylation signal	0.6389
p.S1283F	DO50301	SKCM	ICGC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation blocking phosphorylation signal	0.6389
p.S1283F	DO38069	SKCM	ICGC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation blocking phosphorylation signal	0.6389
p.E179K	TCGA-GN-A263	SKCM	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation altering degron motif	0.7022
p.E179K	DO37766	SKCM	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation altering degron motif	0.7022
p.R184C	TCGA-GU-A763	BLCA	TCGA	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation substituting flanking lysine	0.3333
p.R184C	DO51888	BLCA	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation substituting flanking lysine	0.3333
p.R222Q	TCGA-KK-A59V	PRAD	TCGA	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.0833
p.R222Q	DO234242	ESAD	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.0833
p.R222Q	DO51346	PRAD	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.0833
p.P252H	TCGA-NC-A5HQ	LUSC	TCGA	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1667
p.P252H	DO219201	LUSC	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1667
p.R270L	TCGA-O2-A52S	LUSC	TCGA	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.R270L	DO219221	LUSC	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.R270L	SIDM00623	Other Blood Cancers	GDSC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.R270L	Mo-T	haematopoietic and lymphoid tissue	COSMIC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.A250T	TCGA-VQ-A8PT	STAD	TCGA	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.A250T	DO234313	ESAD	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.A250T	DO51776	STAD	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.E2305K	TCGA-XF-A9SG	BLCA	TCGA	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.1111
p.E2305K	DO51912	BLCA	ICGC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.1111
p.S239C	TCGA-XF-AAMG	BLCA	TCGA	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.2222
p.S239C	DO219049	BLCA	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.2222
p.F1277S	TCGA-Z2-A8RT	SKCM	TCGA	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation altering degron motif	0.7982
p.F1277S	DO51301	SKCM	ICGC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation altering degron motif	0.7982
p.P252S	DO48393	BLCA	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1667
p.P252S	DO229010	COCA	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1667
p.P252S	DO229003	COCA	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1667
p.P252S	DO229346	LAML	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1667
p.S180T	DO228295	BRCA	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation altering degron motif	0.7116
p.K259Q	DO228307	BRCA	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6944
p.G2903D	DO228483	BRCA	ICGC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00305	Ovarian Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00993	Plasma Cell Myeloma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00615	Hepatocellular Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00075	Non-Cancerous	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM01117	Small Cell Lung Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00491	Thyroid Gland Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00315	Glioblastoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00362	Burkitt's Lymphoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM01189	Glioblastoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM01112	Osteosarcoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00619	Thyroid Gland Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM01093	Cervical Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00282	Colorectal Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00556	Neuroblastoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00251	Gastric Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00299	Other Sarcomas	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00214	Colorectal Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00580	Acute Myeloid Leukemia	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00561	Other Blood Cancers	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM01061	Oral Cavity Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00566	Oral Cavity Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00560	Gastric Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00863	Burkitt's Lymphoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00316	Glioblastoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM01033	Bladder Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM01609	Endometrial Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM01659	Kidney Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00165	Other Solid Cancers	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM01682	Gastric Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM01412	Oral Cavity Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00167	Head and Neck Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00166	Other Solid Cancers	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM00160	Biliary Tract Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM01471	Chronic Myelogenous Leukemia	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM01573	Plasma Cell Myeloma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM01435	Hepatocellular Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM01774	Pancreatic Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM01694	B-Lymphoblastic Leukemia	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.G2903D	SIDM01343	Gastric Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3056
p.V2782I	DO228483	BRCA	ICGC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation altering degron motif	0.7076
p.V2782I	DO229010	COCA	ICGC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation altering degron motif	0.7076
p.V2782I	DO229013	COCA	ICGC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation altering degron motif	0.7076
p.V2782I	DO229003	COCA	ICGC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation altering degron motif	0.7076
p.V2782I	DO229346	LAML	ICGC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation altering degron motif	0.7076
p.V2782I	DO229505	LAML	ICGC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation altering degron motif	0.7076
p.D3286N	DO222492	COCA	ICGC	PPTY	ITCH	3280:3283	Mutation rewiring degron network	0.25
p.L1353P	DO50406	ESAD	ICGC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.2778
p.G1269C	DO234151	ESAD	ICGC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.1944
p.L1353R	DO234153	ESAD	ICGC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.2778
p.G1349V	DO234239	ESAD	ICGC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation altering degron motif	0.7532
p.S2304P	DO233784	GACA	ICGC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.1389
p.M248I	DO233728	GACA	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.S180R	DO233850	GACA	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation altering degron motif	0.7427
p.R2779G	DO228915	LICA	ICGC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation altering degron motif	0.7568
p.C235F	DO228936	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation altering degron motif	0.7108
p.L2784F	DO228976	LICA	ICGC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.3056
p.V189L	DO228976	LICA	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.0833
p.R222L	DO228978	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.0833
p.C1276F	DO229028	LICA	ICGC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation altering degron motif	0.7108
p.A250S	DO229027	LICA	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.R225M	DO229035	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1667
p.R225M	DO224610	LUSC	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1667
p.F1282S	DO50957	LICA	ICGC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.2222
p.R236C	DO231690	LINC	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.3056
p.R236C	DO227677	SKCA	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.3056
p.S164A	DO45243	LIRI	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.0833
p.G1349R	DO45141	LIRI	ICGC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation altering degron motif	0.7568
p.E245K	DO45119	LIRI	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.0556
p.T1350K	DO224563	LUSC	ICGC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation altering degron motif	0.7306
p.Q261K	DO224563	LUSC	ICGC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6944
p.A224E	DO228343	MALY	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1389
p.D3281V	DO52655	MALY	ICGC	PPTY	ITCH	3280:3283	Mutation altering degron motif	0.7785
p.E2896K	DO222880	MELA	ICGC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation altering degron motif	0.7022
p.S231A	DO232761	PBCA	ICGC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation altering degron motif	0.7588
p.H182Q	DO219873	SKCA	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.2778
p.F190L	DO223286	UCEC	ICGC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.0556
p.V3293A	SIDM01123	Prostate Carcinoma	GDSC	PPTY	ITCH	3280:3283	Mutation rewiring degron network	0.0556
p.V3293A	NCI-H660	prostate	COSMIC	PPTY	ITCH	3280:3283	Mutation rewiring degron network	0.0556
p.H3282R	SIDM01015	Chronic Myelogenous Leukemia	GDSC	PPTY	ITCH	3280:3283	Mutation altering degron motif	0.8244
p.R270C	SIDM00933	Breast Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.R270C	CAL-51	breast	COSMIC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.S3279P	SIDM01062	Breast Carcinoma	GDSC	PPTY	ITCH	3280:3283	Mutation rewiring degron network	0.3056
p.S3279P	SIDM01080	Oral Cavity Carcinoma	GDSC	PPTY	ITCH	3280:3283	Mutation rewiring degron network	0.3056
p.H2770Y	SIDM00656	Burkitt's Lymphoma	GDSC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.1944
p.H2770Y	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.1944
p.H2770Y	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.1944
p.H2770Y	SIDM00641	Burkitt's Lymphoma	GDSC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.1944
p.H2770Y	SIDM01664	Prostate Carcinoma	GDSC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.1944
p.H2770Y	SIDM01409	Bladder Carcinoma	GDSC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.1944
p.V189M	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.0833
p.V189M	ACH-000825	Lung Cancer	CCLE	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.0833
p.V189M	HOP-92	lung	COSMIC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.0833
p.A228T	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.25
p.A228T	RF-48	stomach	COSMIC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.25
p.P2889A	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.1944
p.P2889A	NCI-H1838	lung	COSMIC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.1944
p.P2889Q	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.1944
p.P2889Q	NCI-H1838	lung	COSMIC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.1944
p.I185F	SIDM00704	Small Cell Lung Carcinoma	GDSC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.1944
p.I185F	ACH-000639	Lung Cancer	CCLE	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.1944
p.I185F	NCI-H211	lung	COSMIC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.1944
p.G233S	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation altering degron motif	0.6993
p.G233S	H513	pleura	COSMIC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation altering degron motif	0.6993
p.P2290L	SIDM00429	B-Lymphoblastic Leukemia	GDSC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation substituting flanking lysine	0.3611
p.P2290L	ACH-000938	Leukemia	CCLE	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation substituting flanking lysine	0.3611
p.P2290L	NALM-6	haematopoietic and lymphoid tissue	COSMIC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation substituting flanking lysine	0.3611
p.R1348Q	SIDM00674	Non-Cancerous	GDSC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation altering degron motif	0.7329
p.R1348Q	SIDM00675	Breast Carcinoma	GDSC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation altering degron motif	0.7329
p.F1354L	SIDM01220	Glioma	GDSC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.25
p.F1354L	ACH-002269	Brain Cancer	CCLE	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.25
p.F1354L	LNZTA3WT4	central nervous system	COSMIC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.25
p.D1285N	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation blocking phosphorylation signal	0.5833
p.D1285N	ACH-000951	Lung Cancer	CCLE	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation blocking phosphorylation signal	0.5833
p.D1285N	NCI-H2342	lung	COSMIC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation blocking phosphorylation signal	0.5833
p.A256T	SIDM01061	Oral Cavity Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.2778
p.A256T	HN	upper aerodigestive tract	COSMIC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.2778
p.K2907E	SIDM01193	Glioma	GDSC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.0833
p.K2907E	ACH-000040	Brain Cancer	CCLE	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.0833
p.K2907E	U-118-MG	central nervous system	COSMIC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.0833
p.T1265I	SIDM00863	Burkitt's Lymphoma	GDSC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation blocking phosphorylation signal	0.5278
p.P2785A	SIDM00720	Mesothelioma	GDSC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.2778
p.P2785A	ACH-000648	Lung Cancer	CCLE	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.2778
p.P2785A	NCI-H28	pleura	COSMIC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.2778
p.R236H	SIDM01480	Ovarian Carcinoma	GDSC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.3056
p.E1280D	SIDM01611	Endometrial Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.2778
p.L2784W	SIDM01450	Gastric Carcinoma	GDSC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation rewiring degron network	0.3056
p.E1340A	SIDM01490	Small Cell Lung Carcinoma	GDSC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.1389
p.E1340A	ACH-000382	Lung Cancer	CCLE	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.1389
p.R269H	ACH-000256	Ovarian Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1389
p.R2895H	BICR22	upper aerodigestive tract	COSMIC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation altering degron motif	0.8244
p.V267F	NCI-H1993	lung	COSMIC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1944
p.R1275Q	HCC2998	large intestine	COSMIC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation altering degron motif	0.7329
p.R1275Q	IGR-1	skin	COSMIC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation altering degron motif	0.7329
p.H2300Y	COLO-783	skin	COSMIC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.25
p.E2893K	EKVX	lung	COSMIC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation rewiring degron network	0.3056
p.P239L	NCI-H1105	lung	COSMIC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.2222
p.G245D	COLO-792	skin	COSMIC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.0556
p.G245D	NCI-H446	lung	COSMIC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.0556
p.K2890N	DU-145	prostate	COSMIC	QKENK	DEG_APCC_KENBOX_2	2894:2898	Mutation substituting flanking lysine	0.3333
p.T1278S	DU-145	prostate	COSMIC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation altering degron motif	0.6005
p.E2304A	HCT-15	large intestine	COSMIC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.1389
p.S2296R	A101D	skin	COSMIC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation altering degron motif	0.7427
p.T248I	RERF-LC-KJ	lung	COSMIC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.V1347F	SK-MES-1	lung	COSMIC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation altering degron motif	0.7068
p.T2302K	FADU	upper aerodigestive tract	COSMIC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.1944
p.D265H	NCI-H2009	lung	COSMIC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.25
p.S2297I	NCI-H1793	lung	COSMIC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation altering degron motif	0.7341
p.D236V	NB13	autonomic ganglia	COSMIC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.3056
p.S2301L	MCC13	skin	COSMIC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.2222
p.R2776H	OCUB-M	breast	COSMIC	KREELQQIL	DEG_APCC_DBOX_1	2775:2783	Mutation altering degron motif	0.8244
p.Y227H	UACC-62	skin	COSMIC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation substituting flanking lysine	0.3333
p.L189S	DND-41	haematopoietic and lymphoid tissue	COSMIC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.0833
p.F232V	HCC2998	large intestine	COSMIC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation altering degron motif	0.7068
p.D179N	YT	haematopoietic and lymphoid tissue	COSMIC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation altering degron motif	0.5821
p.K167R	OE33	oesophagus	COSMIC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.1667
p.D1346N	DMS-53	lung	COSMIC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.3056
p.D1346N	MDA-MB-361	breast	COSMIC	VKTTT	DEG_SPOP_SBC_1	1347:1351	Mutation rewiring degron network	0.3056
p.S2299F	SK-MEL-5	skin	COSMIC	VMTSS	DEG_SPOP_SBC_1	2293:2297	Mutation rewiring degron network	0.2778
p.P234T	T-24	urinary tract	COSMIC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation altering degron motif	0.7031
p.P230S	HCC2998	large intestine	COSMIC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.3056
p.A261T	RF-48	stomach	COSMIC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.7139
p.I181L	Sarc9371	bone	COSMIC	VIDTPEDE	DEG_SCF_FBW7_2	173:180	Mutation rewiring degron network	0.3056
p.T1276A	SNU-423	liver	COSMIC	VKTST	DEG_SPOP_SBC_1	1274:1278	Mutation altering degron motif	0.7139
p.P234Q	NCI-H2009	lung	COSMIC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation altering degron motif	0.7035
p.L235P	SNU-81	large intestine	COSMIC	VVSTS	DEG_SPOP_SBC_1	231:235	Mutation altering degron motif	0.7582
p.S248Y	DU-145	prostate	COSMIC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.G266S	H513	pleura	COSMIC	VTSST	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

XIRP2

UniProt ID: A4UGR9

Entrez ID: 129446

Protein name: Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for XIRP2 in