DegronMD

Uniprot ID: A4UGR9

Source protein: Xin actin-binding repeat-containing protein 2

Source gene: XIRP2

Class: DEG_SPOP_SBC_1

Location: 2293:2297

E3 ligase: SPOP

DEGRON score: 0.8434

ASA_SCORE: 92.24

COIL: 0.825

CONS_SCORE: 0.3301

DSS_SCORE: 0.5411

HELIX: 0.0294

FCONS_SCORE: 0.8869

RIG_SCORE: 0.7144

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2294L	TCGA-63-A5MM	LUSC	TCGA	VMTSS	DEG_SPOP_SBC_1	0.7582
p.P2294L	DO219153	LUSC	ICGC	VMTSS	DEG_SPOP_SBC_1	0.7582
p.S2285R	TCGA-68-7755	LUSC	TCGA	VMTSS	DEG_SPOP_SBC_1	0.1111
p.S2285R	DO26512	LUSC	ICGC	VMTSS	DEG_SPOP_SBC_1	0.1111
p.S2285N	TCGA-A5-A0G2	UCEC	TCGA	VMTSS	DEG_SPOP_SBC_1	0.1111
p.S2285N	DO41235	UCEC	ICGC	VMTSS	DEG_SPOP_SBC_1	0.1111
p.S2293Y	TCGA-AX-A2HC	UCEC	TCGA	VMTSS	DEG_SPOP_SBC_1	0.712
p.S2293Y	DO41572	UCEC	ICGC	VMTSS	DEG_SPOP_SBC_1	0.712
p.S2304F	TCGA-EO-A22U	UCEC	TCGA	VMTSS	DEG_SPOP_SBC_1	0.1389
p.S2304F	TCGA-WE-AAA0	SKCM	TCGA	VMTSS	DEG_SPOP_SBC_1	0.1389
p.S2304F	DO51294	SKCM	ICGC	VMTSS	DEG_SPOP_SBC_1	0.1389
p.S2304F	DO43755	UCEC	ICGC	VMTSS	DEG_SPOP_SBC_1	0.1389
p.S2304F	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	VMTSS	DEG_SPOP_SBC_1	0.1389
p.S2304F	ACH-002215	Lymphoma	CCLE	VMTSS	DEG_SPOP_SBC_1	0.1389
p.S2304F	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	VMTSS	DEG_SPOP_SBC_1	0.1389
p.E2305K	TCGA-XF-A9SG	BLCA	TCGA	VMTSS	DEG_SPOP_SBC_1	0.1111
p.E2305K	DO51912	BLCA	ICGC	VMTSS	DEG_SPOP_SBC_1	0.1111
p.S2304P	DO233784	GACA	ICGC	VMTSS	DEG_SPOP_SBC_1	0.1389
p.P2290L	SIDM00429	B-Lymphoblastic Leukemia	GDSC	VMTSS	DEG_SPOP_SBC_1	0.3611
p.P2290L	ACH-000938	Leukemia	CCLE	VMTSS	DEG_SPOP_SBC_1	0.3611
p.P2290L	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	VMTSS	DEG_SPOP_SBC_1	0.3611
p.H2300Y	COLO-783	skin	COSMIC	VMTSS	DEG_SPOP_SBC_1	0.25
p.E2304A	HCT-15	large_intestine	COSMIC	VMTSS	DEG_SPOP_SBC_1	0.1389
p.S2296R	A101D	skin	COSMIC	VMTSS	DEG_SPOP_SBC_1	0.7427
p.T2302K	FADU	upper_aerodigestive_tract	COSMIC	VMTSS	DEG_SPOP_SBC_1	0.1944
p.S2297I	NCI-H1793	lung	COSMIC	VMTSS	DEG_SPOP_SBC_1	0.7341
p.S2301L	MCC13	skin	COSMIC	VMTSS	DEG_SPOP_SBC_1	0.2222
p.S2299F	SK-MEL-5	skin	COSMIC	VMTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	2293:2297	VMTSS	SPOP	0.8434	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	2029:2033	VMTSS	SPOP	0.9021	More...
Q9NZQ3	NCK-interacting protein with SH3 domain	DEG_SPOP_SBC_1	116:120	VMTSS	SPOP	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VMTSS

Degron related mutations and impact score

Drug responses associated with XIRP2 mutations

All proteins holding degron of VMTSS