DegronMD

Uniprot ID: Q9NZQ3

Source protein: NCK-interacting protein with SH3 domain

Source gene: NCKIPSD

Class: DEG_SPOP_SBC_1

Location: 116:120

E3 ligase: SPOP

DEGRON score: 0.9946

ASA_SCORE: 85.12

COIL: 0.9108

CONS_SCORE: 0.3302

DSS_SCORE: 0.5778

HELIX: 0.0316

FCONS_SCORE: 1.0152

RIG_SCORE: 0.6393

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D123E	TCGA-06-5858	GBM	TCGA	VMTSS	DEG_SPOP_SBC_1	0.25
p.D123E	DO10892	GBM	ICGC	VMTSS	DEG_SPOP_SBC_1	0.25
p.D123N	TCGA-AN-A0XW	BRCA	TCGA	VMTSS	DEG_SPOP_SBC_1	0.25
p.D123N	DO225258	BRCA	ICGC	VMTSS	DEG_SPOP_SBC_1	0.25
p.D123N	DO1873	BRCA	ICGC	VMTSS	DEG_SPOP_SBC_1	0.25
p.S112F	DO220878	MELA	ICGC	VMTSS	DEG_SPOP_SBC_1	0.2222
p.R106C	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	VMTSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	2293:2297	VMTSS	SPOP	0.8434	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	2029:2033	VMTSS	SPOP	0.9021	More...
Q9NZQ3	NCK-interacting protein with SH3 domain	DEG_SPOP_SBC_1	116:120	VMTSS	SPOP	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons