DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VMTSS
Uniprot ID:
Q8IZF6
Source protein:
Adhesion G-protein coupled receptor G4
Source gene:
ADGRG4
Class:
DEG_SPOP_SBC_1
Location:
2029:2033
E3 ligase:
SPOP
DEGRON score:
0.9021
ASA_SCORE:
85.88
COIL:
0.8196
CONS_SCORE:
0.7675
DSS_SCORE:
0.3761
HELIX:
0.0182
FCONS_SCORE:
0.9981
RIG_SCORE:
0.7147
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S2039F
451Lu
skin
COSMIC
VMTSS
DEG_SPOP_SBC_1
0.2778
p.S2030L
SAS
upper_aerodigestive_tract
COSMIC
VMTSS
DEG_SPOP_SBC_1
0.7667
Drug responses associated with ADGRG4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VMTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A4UGR9
Xin actin-binding repeat-containing protein 2
DEG_SPOP_SBC_1
2293:2297
VMTSS
SPOP
0.8434
More...
Q8IZF6
Adhesion G-protein coupled receptor G4
DEG_SPOP_SBC_1
2029:2033
VMTSS
SPOP
0.9021
More...
Q9NZQ3
NCK-interacting protein with SH3 domain
DEG_SPOP_SBC_1
116:120
VMTSS
SPOP
0.9946
More...