DegronMD - Q9NZQ3(NCKIPSD)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D123E	TCGA-06-5858	GBM	TCGA	VMTSS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.25
p.D123E	DO10892	GBM	ICGC	VMTSS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.25
p.D123N	TCGA-AN-A0XW	BRCA	TCGA	VMTSS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.25
p.D123N	DO225258	BRCA	ICGC	VMTSS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.25
p.D123N	DO1873	BRCA	ICGC	VMTSS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.25
p.S229N	TCGA-EE-A2MM	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1389
p.D224G	TCGA-F5-6814	READ	TCGA	VSSTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.2778
p.R100Q	TCGA-KK-A59V	PRAD	TCGA	QRGVLQKLI	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.25
p.R100Q	DO51346	PRAD	ICGC	QRGVLQKLI	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.25
p.D224V	TCGA-QK-A6IH	HNSC	TCGA	VSSTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.2778
p.E88Q	DO225258	BRCA	ICGC	QRGVLQKLI	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.3056
p.G208S	DO225371	BRCA	ICGC	VSSTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0556
p.T218M	DO233182	GACA	ICGC	VSSTS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7423
p.D217V	DO50004	HNSC	ICGC	VSSTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.S86R	DO229022	LICA	ICGC	QRGVLQKLI	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.25
p.S112F	DO220878	MELA	ICGC	VMTSS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.2222
p.S222N	DO222678	MELA	ICGC	VSSTS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7069
p.S222N	DO37770	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7069
p.S224I	DO232224	PBCA	ICGC	VSSTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.2778
p.D217G	DO36556	READ	ICGC	VSSTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.P228S	DO37667	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1667
p.S212T	DO229245	THCA	ICGC	VSSTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1667
p.S231N	SIDM00945	Colorectal Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0833
p.S231N	ACH-000895	Colon/Colorectal Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0833
p.S231N	CL-34	large intestine	COSMIC	VSSTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0833
p.R106C	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	QRGVLQKLI	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.0833
p.R106C	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	VMTSS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.0556
p.R80W	ACH-000132	Ovarian Cancer	CCLE	QRGVLQKLI	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.0833
p.R80W	ACH-000476	Liver Cancer	CCLE	QRGVLQKLI	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.0833
p.R80W	ACH-000843	Lung Cancer	CCLE	QRGVLQKLI	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.0833
p.R80W	ACH-001109	Rhabdoid	CCLE	QRGVLQKLI	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.0833
p.S224N	CL-34	large intestine	COSMIC	VSSTS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.2778

Kaplan plot for NCKIPSD in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NCKIPSD

UniProt ID: Q9NZQ3

Entrez ID: 51517

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NCKIPSD in