DegronMD

Uniprot ID: Q9NZQ3

Source protein: NCK-interacting protein with SH3 domain

Source gene: NCKIPSD

Class: DEG_APCC_DBOX_1

Location: 89:97

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6694

ASA_SCORE: 56.6556

COIL: 0.102

CONS_SCORE: 0.4893

DSS_SCORE: 0.4496

HELIX: 0.8949

FCONS_SCORE: 1.2568

RIG_SCORE: 0.7773

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R100Q	TCGA-KK-A59V	PRAD	TCGA	QRGVLQKLI	DEG_APCC_DBOX_1	0.25
p.R100Q	DO51346	PRAD	ICGC	QRGVLQKLI	DEG_APCC_DBOX_1	0.25
p.E88Q	DO225258	BRCA	ICGC	QRGVLQKLI	DEG_APCC_DBOX_1	0.3056
p.S86R	DO229022	LICA	ICGC	QRGVLQKLI	DEG_APCC_DBOX_1	0.25
p.R106C	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	QRGVLQKLI	DEG_APCC_DBOX_1	0.0833
p.R80W	ACH-000132	Ovarian Cancer	CCLE	QRGVLQKLI	DEG_APCC_DBOX_1	0.0833
p.R80W	ACH-000476	Liver Cancer	CCLE	QRGVLQKLI	DEG_APCC_DBOX_1	0.0833
p.R80W	ACH-000843	Lung Cancer	CCLE	QRGVLQKLI	DEG_APCC_DBOX_1	0.0833
p.R80W	ACH-001109	Rhabdoid	CCLE	QRGVLQKLI	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZQ3	NCK-interacting protein with SH3 domain	DEG_APCC_DBOX_1	89:97	QRGVLQKLI	APC,CDC20,FZR1	0.6694	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons